1wbe

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{{Seed}}
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{{STRUCTURE_1wbe| PDB=1wbe | SCENE= }}
{{STRUCTURE_1wbe| PDB=1wbe | SCENE= }}
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'''X-RAY STRUCTURE OF BOVINE GLTP'''
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===X-RAY STRUCTURE OF BOVINE GLTP===
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==Overview==
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Glycolipids participate in many important cellular processes and they are bound and transferred with high specificity by glycolipid transfer protein (GLTP). We have solved three different X-ray structures of bovine GLTP at 1.4 angstroms, 1.6 angstroms and 1.8 angstroms resolution, all with a bound fatty acid or glycolipid. The 1.4 angstroms structure resembles the recently characterized apo-form of the human GLTP but the other two structures represent an intermediate conformation of the apo-GLTPs and the human lactosylceramide-bound GLTP structure. These novel structures give insight into the mechanism of lipid binding and how GLTP may conformationally adapt to different lipids. Furthermore, based on the structural comparison of the GLTP structures and the three-dimensional models of the related Podospora anserina HET-C2 and Arabidopsis thaliana accelerated cell death protein, ACD11, we give structural explanations for their specific lipid binding properties.
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(as it appears on PubMed at http://www.pubmed.gov), where 16309699 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16309699}}
==About this Structure==
==About this Structure==
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[[Category: Glycolipid transfer]]
[[Category: Glycolipid transfer]]
[[Category: Lipid transport]]
[[Category: Lipid transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:25:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:56:07 2008''

Revision as of 05:56, 28 July 2008

Image:1wbe.png

Template:STRUCTURE 1wbe

X-RAY STRUCTURE OF BOVINE GLTP

Template:ABSTRACT PUBMED 16309699

About this Structure

1WBE is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structural evidence for adaptive ligand binding of glycolipid transfer protein., Airenne TT, Kidron H, Nymalm Y, Nylund M, West G, Mattjus P, Salminen TA, J Mol Biol. 2006 Jan 13;355(2):224-36. Epub 2005 Nov 8. PMID:16309699

Page seeded by OCA on Mon Jul 28 08:56:07 2008

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