9w8p
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Isomerase at 260K== | |
| - | + | <StructureSection load='9w8p' size='340' side='right'caption='[[9w8p]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9w8p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9W8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9W8P FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9w8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9w8p OCA], [https://pdbe.org/9w8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9w8p RCSB], [https://www.ebi.ac.uk/pdbsum/9w8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9w8p ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Guven | + | == Function == |
| + | [https://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: DeMirci H]] | ||
| + | [[Category: Guven O]] | ||
Current revision
Isomerase at 260K
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