9jxq
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Complex of XPR1-KIDINS220== | |
| - | + | <StructureSection load='9jxq' size='340' side='right'caption='[[9jxq]], [[Resolution|resolution]] 3.44Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9jxq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JXQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.44Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jxq OCA], [https://pdbe.org/9jxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jxq RCSB], [https://www.ebi.ac.uk/pdbsum/9jxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jxq ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/KDIS_HUMAN KDIS_HUMAN] Spastic paraplegia-intellectual disability-nystagmus-obesity syndrome. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KDIS_HUMAN KDIS_HUMAN] Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.<ref>PMID:18089783</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bai Z]] | ||
| + | [[Category: Corry B]] | ||
| + | [[Category: Gu C]] | ||
| + | [[Category: Han Y]] | ||
| + | [[Category: Jessen H]] | ||
| + | [[Category: Jin R]] | ||
| + | [[Category: Lei M]] | ||
| + | [[Category: Shears S]] | ||
| + | [[Category: Sun Y]] | ||
| + | [[Category: Wallis C]] | ||
| + | [[Category: Wang H]] | ||
| + | [[Category: Wang X]] | ||
| + | [[Category: Zhang Y]] | ||
Current revision
Complex of XPR1-KIDINS220
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