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9kxk

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Current revision (08:08, 11 December 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9kxk is ON HOLD until 2026-12-06
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==Crystal structure of the PIN1 and fragment 54 complex==
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<StructureSection load='9kxk' size='340' side='right'caption='[[9kxk]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
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Authors: Xiao, Q.J., Wu, T.T., Shu, H.L., Qin, W.M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9kxk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KXK FirstGlance]. <br>
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Description: Crystal structure of the PIN1 and fragment 54 complex
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EFQ:1-(1~{H}-pyrazol-3-yl)ethanone'>A1EFQ</scene>, <scene name='pdbligand=PE8:3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL'>PE8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Shu, H.L]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kxk OCA], [https://pdbe.org/9kxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kxk RCSB], [https://www.ebi.ac.uk/pdbsum/9kxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kxk ProSAT]</span></td></tr>
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[[Category: Xiao, Q.J]]
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</table>
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[[Category: Wu, T.T]]
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== Function ==
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[[Category: Qin, W.M]]
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[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Qin WM]]
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[[Category: Shu HL]]
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[[Category: Wu TT]]
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[[Category: Xiao QJ]]

Current revision

Crystal structure of the PIN1 and fragment 54 complex

PDB ID 9kxk

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