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9pzv

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m (Protected "9pzv" [edit=sysop:move=sysop])
Current revision (13:09, 17 December 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9pzv is ON HOLD until Paper Publication
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==Native GluN1/GluN2A in complex with 5F11 and 3D2 Fabs, local ATD dimer==
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<StructureSection load='9pzv' size='340' side='right'caption='[[9pzv]], [[Resolution|resolution]] 3.92&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9pzv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9PZV FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.92&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9pzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9pzv OCA], [https://pdbe.org/9pzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9pzv RCSB], [https://www.ebi.ac.uk/pdbsum/9pzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9pzv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NMDZ1_MOUSE NMDZ1_MOUSE] Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:12008020, PubMed:12860921, PubMed:14602821, PubMed:1532151, PubMed:8060614, PubMed:9049108). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP) (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:12008020, PubMed:1532151, PubMed:7790891, PubMed:8060614). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (PubMed:12860921). Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:12008020, PubMed:14602821).[UniProtKB:Q05586]<ref>PMID:12008020</ref> <ref>PMID:12860921</ref> <ref>PMID:14602821</ref> <ref>PMID:1532151</ref> <ref>PMID:7790891</ref> <ref>PMID:8060614</ref> <ref>PMID:9049108</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Gouaux E]]
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[[Category: Kim J]]

Current revision

Native GluN1/GluN2A in complex with 5F11 and 3D2 Fabs, local ATD dimer

PDB ID 9pzv

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