1zt4
From Proteopedia
(New page: 200px<br /> <applet load="1zt4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zt4, resolution 3.000Å" /> '''The crystal struct...) |
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| - | [[Image:1zt4.gif|left|200px]]<br /> | + | [[Image:1zt4.gif|left|200px]]<br /><applet load="1zt4" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1zt4" size=" | + | |
caption="1zt4, resolution 3.000Å" /> | caption="1zt4, resolution 3.000Å" /> | ||
'''The crystal structure of human CD1d with and without alpha-Galactosylceramide'''<br /> | '''The crystal structure of human CD1d with and without alpha-Galactosylceramide'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The glycolipid alpha-galactosylceramide binds with high affinity to CD1d | + | The glycolipid alpha-galactosylceramide binds with high affinity to CD1d and stimulates natural killer T cells. Here we report the crystal structure of human CD1d in complex with synthetic alpha-galactosylceramide at a resolution of 3.0 A. The structure shows a tightly fit lipid in the CD1d binding groove, with the sphingosine chain bound in the C' pocket and the longer acyl chain anchored in the A' pocket. We also present the CD1d structure without lipid, which has a more open conformation of the binding groove, suggesting a dual conformation of CD1d in which the 'open' conformation is more able to load lipids. These structures provide clues as to how CD1 molecules load glycolipids as well as data to guide the design of new therapeutic agents. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ZT4 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with AGH as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1ZT4 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=AGH:'>AGH</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZT4 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Besra, G | + | [[Category: Besra, G S.]] |
[[Category: Cerundolo, V.]] | [[Category: Cerundolo, V.]] | ||
| - | [[Category: Fersht, A | + | [[Category: Fersht, A R.]] |
| - | [[Category: Gadola, S | + | [[Category: Gadola, S D.]] |
| - | [[Category: Jones, E | + | [[Category: Jones, E Y.]] |
[[Category: Koch, M.]] | [[Category: Koch, M.]] | ||
[[Category: Mathew, B.]] | [[Category: Mathew, B.]] | ||
[[Category: Ritter, G.]] | [[Category: Ritter, G.]] | ||
| - | [[Category: SPINE, Structural | + | [[Category: SPINE, Structural Proteomics in Europe.]] |
| - | [[Category: Schmidt, R | + | [[Category: Schmidt, R R.]] |
[[Category: Shepherd, D.]] | [[Category: Shepherd, D.]] | ||
| - | [[Category: Stronge, V | + | [[Category: Stronge, V S.]] |
[[Category: AGH]] | [[Category: AGH]] | ||
[[Category: alpha-galactosylceramide]] | [[Category: alpha-galactosylceramide]] | ||
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[[Category: structural proteomics in europe]] | [[Category: structural proteomics in europe]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:18:51 2008'' |
Revision as of 14:18, 21 February 2008
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The crystal structure of human CD1d with and without alpha-Galactosylceramide
Contents |
Overview
The glycolipid alpha-galactosylceramide binds with high affinity to CD1d and stimulates natural killer T cells. Here we report the crystal structure of human CD1d in complex with synthetic alpha-galactosylceramide at a resolution of 3.0 A. The structure shows a tightly fit lipid in the CD1d binding groove, with the sphingosine chain bound in the C' pocket and the longer acyl chain anchored in the A' pocket. We also present the CD1d structure without lipid, which has a more open conformation of the binding groove, suggesting a dual conformation of CD1d in which the 'open' conformation is more able to load lipids. These structures provide clues as to how CD1 molecules load glycolipids as well as data to guide the design of new therapeutic agents.
Disease
Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]
About this Structure
1ZT4 is a Protein complex structure of sequences from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
The crystal structure of human CD1d with and without alpha-galactosylceramide., Koch M, Stronge VS, Shepherd D, Gadola SD, Mathew B, Ritter G, Fersht AR, Besra GS, Schmidt RR, Jones EY, Cerundolo V, Nat Immunol. 2005 Aug;6(8):819-26. Epub 2005 Jul 10. PMID:16007090
Page seeded by OCA on Thu Feb 21 16:18:51 2008
Categories: Homo sapiens | Protein complex | Besra, G S. | Cerundolo, V. | Fersht, A R. | Gadola, S D. | Jones, E Y. | Koch, M. | Mathew, B. | Ritter, G. | SPINE, Structural Proteomics in Europe. | Schmidt, R R. | Shepherd, D. | Stronge, V S. | AGH | Alpha-galactosylceramide | Alpha-galcer | Cd1 | Empty binding groove | Glycolipid | Human cd1d | Mhc class i | Spine | Structural genomics | Structural proteomics in europe
