1wmg

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{{STRUCTURE_1wmg| PDB=1wmg | SCENE= }}
{{STRUCTURE_1wmg| PDB=1wmg | SCENE= }}
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'''Crystal structure of the UNC5H2 death domain'''
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===Crystal structure of the UNC5H2 death domain===
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==Overview==
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UNC5Hs (UNC5H1-4) are netrin 1 receptors that are involved in axonal guidance and neuronal migration. They are dependence receptors that mediate apoptosis in the absence of netrin 1. UNC5H2-induced apoptosis depends on the interaction of the death domain at the C-terminus with the DAP-kinase death domain and caspase cleavage near the transmembrane region. Here, the crystal structure of the mouse UNC5H2 death domain has been determined at 2.1 A resolution. The domain adopts a six-helix bundle fold, which is similar to those of the other members of the death-domain superfamily. The UNC5H2 death domain is a dimer in the crystal and in solution. This homodimerized structure may represent the structure of the death domain when netrin 1 binds to the UNC5H2 receptor. Homodimerization of UNC5H2 may block the access of caspase to the cleavage site. In the death-domain dimer, residues in alpha3 and the 3(10)-helix preceding alpha3 and the residues in alpha4 make significant contacts, mainly by hydrophobic and van der Waals interactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 17139086 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17139086}}
==About this Structure==
==About this Structure==
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[[Category: Six helix bundle]]
[[Category: Six helix bundle]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:52:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:31:40 2008''

Revision as of 05:31, 28 July 2008

Image:1wmg.png

Template:STRUCTURE 1wmg

Crystal structure of the UNC5H2 death domain

Template:ABSTRACT PUBMED 17139086

About this Structure

1WMG is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of the UNC5H2 death domain., Handa N, Kukimoto-Niino M, Akasaka R, Murayama K, Terada T, Inoue M, Yabuki T, Aoki M, Seki E, Matsuda T, Nunokawa E, Tanaka A, Hayashizaki Y, Kigawa T, Shirouzu M, Yokoyama S, Acta Crystallogr D Biol Crystallogr. 2006 Dec;62(Pt 12):1502-9. Epub 2006, Nov 23. PMID:17139086

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