1wmy

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[[Image:1wmy.gif|left|200px]]
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{{STRUCTURE_1wmy| PDB=1wmy | SCENE= }}
{{STRUCTURE_1wmy| PDB=1wmy | SCENE= }}
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'''Crystal Structure of C-type Lectin CEL-I from Cucumaria echinata'''
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===Crystal Structure of C-type Lectin CEL-I from Cucumaria echinata===
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==Overview==
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CEL-I is a C-type lectin, purified from the sea cucumber Cucumaria echinata, that shows a high specificity for N-acetylgalactosamine (GalNAc). We determined the crystal structures of CEL-I and its complex with GalNAc at 2.0 and 1.7 A resolution, respectively. CEL-I forms a disulfide-linked homodimer and contains two intramolecular disulfide bonds, although it lacks one intramolecular disulfide bond that is widely conserved among various C-type carbohydrate recognition domains (CRDs). Although the sequence similarity of CEL-I with other C-type CRDs is low, the overall folding of CEL-I was quite similar to those of other C-type CRDs. The structure of the complex with GalNAc revealed that the basic recognition mode of GalNAc was very similar to that for the GalNAc-binding mutant of the mannose-binding protein. However, the acetamido group of GalNAc appeared to be recognized more strongly by the combination of hydrogen bonds to Arg115 and van der Waals interaction with Gln70. Mutational analyses, in which Gln70 and/or Arg115 were replaced by alanine, confirmed that these residues contributed to GalNAc recognition in a cooperative manner.
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The line below this paragraph, {{ABSTRACT_PUBMED_15319425}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15319425 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15319425}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Characteristic recognition of N-acetylgalactosamine by an invertebrate C-type Lectin, CEL-I, revealed by X-ray crystallographic analysis., Sugawara H, Kusunoki M, Kurisu G, Fujimoto T, Aoyagi H, Hatakeyama T, J Biol Chem. 2004 Oct 22;279(43):45219-25. Epub 2004 Aug 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15319425 15319425]
Characteristic recognition of N-acetylgalactosamine by an invertebrate C-type Lectin, CEL-I, revealed by X-ray crystallographic analysis., Sugawara H, Kusunoki M, Kurisu G, Fujimoto T, Aoyagi H, Hatakeyama T, J Biol Chem. 2004 Oct 22;279(43):45219-25. Epub 2004 Aug 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15319425 15319425]
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Crystallization and preliminary crystallographic study of an invertebrate C-type lectin, CEL-I, from the marine invertebrate Cucumaria echinata., Hatakeyama T, Matsuo N, Aoyagi H, Sugawara H, Uchida T, Kurisu G, Kusunoki M, Acta Crystallogr D Biol Crystallogr. 2002 Jan;58(Pt 1):143-4. Epub 2001, Dec 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11752793 11752793]
[[Category: Cucumaria echinata]]
[[Category: Cucumaria echinata]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Invertebrate]]
[[Category: Invertebrate]]
[[Category: N-acetylgalactosamine]]
[[Category: N-acetylgalactosamine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:16:51 2008''

Revision as of 00:16, 29 July 2008

Image:1wmy.png

Template:STRUCTURE 1wmy

Crystal Structure of C-type Lectin CEL-I from Cucumaria echinata

Template:ABSTRACT PUBMED 15319425

About this Structure

1WMY is a Single protein structure of sequence from Cucumaria echinata. Full crystallographic information is available from OCA.

Reference

Characteristic recognition of N-acetylgalactosamine by an invertebrate C-type Lectin, CEL-I, revealed by X-ray crystallographic analysis., Sugawara H, Kusunoki M, Kurisu G, Fujimoto T, Aoyagi H, Hatakeyama T, J Biol Chem. 2004 Oct 22;279(43):45219-25. Epub 2004 Aug 19. PMID:15319425

Crystallization and preliminary crystallographic study of an invertebrate C-type lectin, CEL-I, from the marine invertebrate Cucumaria echinata., Hatakeyama T, Matsuo N, Aoyagi H, Sugawara H, Uchida T, Kurisu G, Kusunoki M, Acta Crystallogr D Biol Crystallogr. 2002 Jan;58(Pt 1):143-4. Epub 2001, Dec 21. PMID:11752793

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