1wn4

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{{STRUCTURE_1wn4| PDB=1wn4 | SCENE= }}
{{STRUCTURE_1wn4| PDB=1wn4 | SCENE= }}
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'''NMR Structure of VoNTR'''
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===NMR Structure of VoNTR===
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==Overview==
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The cyclotides are the largest family of naturally occurring circular proteins. The mechanism by which the termini of these gene-encoded proteins are linked seamlessly with a peptide bond to form a circular backbone is unknown. Here we report cyclotide-encoding cDNA sequences from the plant Viola odorata and compare them with those from an evolutionarily distinct species, Oldenlandia affinis. Individual members of this multigene family encode one to three mature cyclotide domains. These domains are preceded by N-terminal repeat regions (NTRs) that are conserved within a plant species but not between species. We have structurally characterized peptides corresponding to these NTRs and show that, despite them having no sequence homology, they form a structurally conserved alpha-helical motif. This structural conservation suggests a vital role for the NTR in the in vivo folding, processing, or detoxification of cyclotide domains from the precursor protein.
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{{ABSTRACT_PUBMED_15328347}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN4 OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WN4 OCA].
==Reference==
==Reference==
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[[Category: Waine, C.]]
[[Category: Waine, C.]]
[[Category: Helix]]
[[Category: Helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:54:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:27:19 2008''

Revision as of 03:27, 29 July 2008

Image:1wn4.png

Template:STRUCTURE 1wn4

NMR Structure of VoNTR

Template:ABSTRACT PUBMED 15328347

About this Structure

Full experimental information is available from OCA.

Reference

Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins., Dutton JL, Renda RF, Waine C, Clark RJ, Daly NL, Jennings CV, Anderson MA, Craik DJ, J Biol Chem. 2004 Nov 5;279(45):46858-67. Epub 2004 Aug 24. PMID:15328347

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