9ssp

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m (Protected "9ssp" [edit=sysop:move=sysop])
Current revision (07:19, 15 October 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9ssp is ON HOLD
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==Human Methionine Synthase With Methyltetrahydrofolate, N-Half From Full-Length==
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<StructureSection load='9ssp' size='340' side='right'caption='[[9ssp]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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Authors: Ferreira, D.S.M., Yue, W.W., McCorvie, T.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9ssp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SSP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SSP FirstGlance]. <br>
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Description: Human Methionine Synthase With Methyltetrahydrofolate, N-Half From Full-Length
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=THH:N-[4-({[(6S)-2-AMINO-4-HYDROXY-5-METHYL-5,6,7,8-TETRAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GLUTAMIC+ACID'>THH</scene></td></tr>
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[[Category: Mccorvie, T.J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ssp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ssp OCA], [https://pdbe.org/9ssp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ssp RCSB], [https://www.ebi.ac.uk/pdbsum/9ssp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ssp ProSAT]</span></td></tr>
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[[Category: Yue, W.W]]
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</table>
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[[Category: Ferreira, D.S.M]]
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== Disease ==
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[https://www.uniprot.org/uniprot/METH_HUMAN METH_HUMAN] Defects in MTR are the cause of methylcobalamin deficiency type G (cblG) [MIM:[https://omim.org/entry/250940 250940]; also known as homocystinuria-megaloblastic anemia complementation type G. It is an autosomal recessive inherited disease that causes mental retardation, macrocytic anemia, and homocystinuria. Mild deficiency in MS activity could be associated with mild hyperhomocysteinemia, a risk factor for cardiovascular disease and possibly neural tube defects. MS mutations could also be involved in tumorigenesis. Defects in MTR may be a cause of susceptibility to folate-sensitive neural tube defects (FS-NTD) [MIM:[https://omim.org/entry/601634 601634]. The most common NTDs are open spina bifida (myelomeningocele) and anencephaly. Genetic defects in MTR may affect the risk of spina bifida via the maternal rather than the embryonic genotype.<ref>PMID:12375236</ref> <ref>PMID:15979034</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/METH_HUMAN METH_HUMAN] Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Ferreira DSM]]
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[[Category: McCorvie TJ]]
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[[Category: Yue WW]]

Current revision

Human Methionine Synthase With Methyltetrahydrofolate, N-Half From Full-Length

PDB ID 9ssp

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