1woe

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[[Image:1woe.gif|left|200px]]
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{{Seed}}
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[[Image:1woe.png|left|200px]]
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{{STRUCTURE_1woe| PDB=1woe | SCENE= }}
{{STRUCTURE_1woe| PDB=1woe | SCENE= }}
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'''X-ray structure of a Z-DNA hexamer d(CGCGCG)'''
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===X-ray structure of a Z-DNA hexamer d(CGCGCG)===
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==Overview==
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In order to reveal the hydration structure of Z-DNA, a neutron diffraction study has been carried out at 1.8 A resolution on a Z-DNA hexamer d(CGCGCG). Neutron diffraction data were collected with the BIX-3 single-crystal diffractometer at the JRR-3 reactor in the Japan Atomic Energy Research Institute (JAERI) using a large crystal (1.6 mm3) obtained from D2O solution. It has been found that almost all the guanine bases have participated in H/D exchange at the C8-H8 group, consistent with the acidic nature of this bond. 44 water molecules were found in the nuclear density maps, of which 29 showed the entire contour of all three atoms (D-O-D). The remaining 15 water molecules had a simple spherical shape, indicating that they were rotationally disordered. An interesting relationship was found between the orientational disorder of the water molecules and their locations. Almost all water molecules in the minor groove were well ordered in the crystal, while 40% of the water molecules in the major groove were rotationally disordered. The hydrogen-bonding networks in the hydration shells have two structural aspects: flexibility and regularity.
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The line below this paragraph, {{ABSTRACT_PUBMED_16041074}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16041074 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16041074}}
==About this Structure==
==About this Structure==
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[[Category: Spermine]]
[[Category: Spermine]]
[[Category: Z-dna]]
[[Category: Z-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:56:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:39:56 2008''

Revision as of 23:39, 27 July 2008

Image:1woe.png

Template:STRUCTURE 1woe

X-ray structure of a Z-DNA hexamer d(CGCGCG)

Template:ABSTRACT PUBMED 16041074

About this Structure

Full crystallographic information is available from OCA.

Reference

The hydration structure of a Z-DNA hexameric duplex determined by a neutron diffraction technique., Chatake T, Tanaka I, Umino H, Arai S, Niimura N, Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1088-98. Epub 2005, Jul 20. PMID:16041074

Page seeded by OCA on Mon Jul 28 02:39:56 2008

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