1wpo

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[[Image:1wpo.gif|left|200px]]
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{{Seed}}
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[[Image:1wpo.png|left|200px]]
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{{STRUCTURE_1wpo| PDB=1wpo | SCENE= }}
{{STRUCTURE_1wpo| PDB=1wpo | SCENE= }}
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'''HYDROLYTIC ENZYME HUMAN CYTOMEGALOVIRUS PROTEASE'''
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===HYDROLYTIC ENZYME HUMAN CYTOMEGALOVIRUS PROTEASE===
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==Overview==
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Human cytomegalovirus (hCMV), a herpesvirus, infects up to 70% of the general population in the United States and can cause morbidity and mortality in immunosuppressed individuals (organ-transplant recipients and AIDS patients) and congenitally infected newborns. hCMV protease is essential for the production of mature infectious virions, as it performs proteolytic processing near the carboxy terminus (M-site) of the viral assembly protein precursor. hCMV protease is a serine protease, although it has little homology to other clans of serine proteases. Here we report the crystal structure of hCMV protease at 2.0 angstroms resolution, and show that it possesses a new polypeptide backbone fold. Ser 132 and His 63 are found in close proximity in the active site, confirming earlier biochemical and mutagenesis studies. The structure suggests that the third member of the triad is probably His 157. A dimer of the protease with an extensive interface is found in the crystal structure. This structure information will help in the design and optimization of inhibitors against herpesvirus proteases.
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The line below this paragraph, {{ABSTRACT_PUBMED_8805706}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8805706 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8805706}}
==About this Structure==
==About this Structure==
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[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Viral protease]]
[[Category: Viral protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:59:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:18:12 2008''

Revision as of 23:18, 28 July 2008

Image:1wpo.png

Template:STRUCTURE 1wpo

HYDROLYTIC ENZYME HUMAN CYTOMEGALOVIRUS PROTEASE

Template:ABSTRACT PUBMED 8805706

About this Structure

1WPO is a Single protein structure of sequence from Human herpesvirus 5. Full crystallographic information is available from OCA.

Reference

A new serine-protease fold revealed by the crystal structure of human cytomegalovirus protease., Tong L, Qian C, Massariol MJ, Bonneau PR, Cordingley MG, Lagace L, Nature. 1996 Sep 19;383(6597):272-5. PMID:8805706

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