1wr1

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{{STRUCTURE_1wr1| PDB=1wr1 | SCENE= }}
{{STRUCTURE_1wr1| PDB=1wr1 | SCENE= }}
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'''The complex sturcture of Dsk2p UBA with ubiquitin'''
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===The complex sturcture of Dsk2p UBA with ubiquitin===
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==Overview==
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The ubiquitin-associated (UBA) domain is one of the most frequently occurring motifs that recognize ubiquitin tags. Dsk2p, a UBA-containing protein from Saccharomyces cerevisiae, is involved in the ubiquitin-proteasome proteolytic pathway and has been implicated in spindle pole duplication. Here we present the solution structure of the UBA domain of Dsk2p (Dsk2(UBA)) in complex with ubiquitin. The structure reveals that the UBA domain uses a mode of ubiquitin recognition that is similar to that of the CUE domain, another ubiquitin binding motif that shares low sequence homology but high structural similarity with UBA domains. These two domains, as well as the structurally unrelated ubiquitin binding motif UIM, provide a common, crucial recognition site for ubiquitin, comprising a hydrogen-bonding acceptor for the amide group of Gly-47, and a methyl group that packs against the hydrophobic pocket of ubiquitin formed by Leu-8, Ile-44, His-68, and Val-70.
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(as it appears on PubMed at http://www.pubmed.gov), where 15837191 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15837191}}
==About this Structure==
==About this Structure==
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1WR1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WR1 OCA].
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1WR1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WR1 OCA].
==Reference==
==Reference==
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[[Category: Uba domain]]
[[Category: Uba domain]]
[[Category: Uba-ubiquitin complex]]
[[Category: Uba-ubiquitin complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:02:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:13:21 2008''

Revision as of 05:13, 28 July 2008

Image:1wr1.png

Template:STRUCTURE 1wr1

The complex sturcture of Dsk2p UBA with ubiquitin

Template:ABSTRACT PUBMED 15837191

About this Structure

1WR1 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

Structure of the UBA domain of Dsk2p in complex with ubiquitin molecular determinants for ubiquitin recognition., Ohno A, Jee J, Fujiwara K, Tenno T, Goda N, Tochio H, Kobayashi H, Hiroaki H, Shirakawa M, Structure. 2005 Apr;13(4):521-32. PMID:15837191

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