9wxm

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Current revision (07:55, 19 November 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9wxm is ON HOLD until Paper Publication
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==Cryo-EM structure of the full-length GPR15L bound GPR15-Gi complex==
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<StructureSection load='9wxm' size='340' side='right'caption='[[9wxm]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9wxm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WXM FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9wxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wxm OCA], [https://pdbe.org/9wxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wxm RCSB], [https://www.ebi.ac.uk/pdbsum/9wxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wxm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GP15L_HUMAN GP15L_HUMAN] Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15 (PubMed:28900043, PubMed:28936214). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May regulate keratinocyte proliferation (PubMed:29872130). In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation (PubMed:35704588).<ref>PMID:25351403</ref> <ref>PMID:28900043</ref> <ref>PMID:28936214</ref> <ref>PMID:29872130</ref> <ref>PMID:35704588</ref> Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus (PubMed:25585381).<ref>PMID:25585381</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Han S]]
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[[Category: Wu B]]
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[[Category: Zhao Q]]

Current revision

Cryo-EM structure of the full-length GPR15L bound GPR15-Gi complex

PDB ID 9wxm

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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