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1wrp

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[[Image:1wrp.gif|left|200px]]
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{{STRUCTURE_1wrp| PDB=1wrp | SCENE= }}
{{STRUCTURE_1wrp| PDB=1wrp | SCENE= }}
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'''FLEXIBILITY OF THE DNA-BINDING DOMAINS OF TRP REPRESSOR'''
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===FLEXIBILITY OF THE DNA-BINDING DOMAINS OF TRP REPRESSOR===
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==Overview==
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An orthorhombic crystal form of trp repressor (aporepressor plus L-tryptophan ligand) was solved by molecular replacement, refined to 1.65 A resolution, and compared to the structure of the repressor in trigonal crystals. Even though these two crystal forms of repressor were grown under identical conditions, the refined structures have distinctly different conformations of the DNA-binding domains. Unlike the repressor/aporepressor structural transition, the conformational shift is not caused by the binding or loss of the L-tryptophan ligand. We conclude that while L-tryptophan binding is essential for forming a specific complex with trp operator DNA, the corepressor ligand does not lock the repressor into a single conformation that is complementary to the operator. This flexibility may be required by the various binding modes proposed for trp repressor in its search for and adherence to its three different operator sites.
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(as it appears on PubMed at http://www.pubmed.gov), where 3375234 is the PubMed ID number.
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{{ABSTRACT_PUBMED_3375234}}
==About this Structure==
==About this Structure==
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[[Category: Sigler, P B.]]
[[Category: Sigler, P B.]]
[[Category: Dna binding regulatory protein]]
[[Category: Dna binding regulatory protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:03:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:47:12 2008''

Revision as of 11:47, 27 July 2008

Image:1wrp.png

Template:STRUCTURE 1wrp

FLEXIBILITY OF THE DNA-BINDING DOMAINS OF TRP REPRESSOR

Template:ABSTRACT PUBMED 3375234

About this Structure

1WRP is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Flexibility of the DNA-binding domains of trp repressor., Lawson CL, Zhang RG, Schevitz RW, Otwinowski Z, Joachimiak A, Sigler PB, Proteins. 1988;3(1):18-31. PMID:3375234

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