1wrt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1wrt.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1wrt.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1wrt| PDB=1wrt | SCENE= }}
{{STRUCTURE_1wrt| PDB=1wrt | SCENE= }}
-
'''NMR STUDY OF APO TRP REPRESSOR'''
+
===NMR STUDY OF APO TRP REPRESSOR===
-
==Overview==
+
<!--
-
The solution structures of the trp-repressor from Escherichia coli in both the liganded (holo-) and unliganded (apo-) form, have been refined by restrained molecular dynamics with simulated annealing using the program XPLOR and additional experimental constraints. The ensemble of refined holorepressor structures have a root-mean-square deviation (r.m.s.d.) of 0.8 A relative to the average structure for the backbone of the dimer core (helices A, B, C, A', B', C') and 2.5 A for the helix-turn-helix DNA-binding domain (helices D and E). The corresponding values for the aporepressor are 0.9 A for the backbone of the ABC-dimer core and 3.2 A for the DE helix-turn-helix. The r.m.s.d. of the average structures from the corresponding crystal structures are 2.3 A for the holorepressor ABC core and 4.2 A for its DE region; 2.3 A for the aporepressor core and 5.5 A for its DE region. The relative disorder of the DNA-binding domain is reflected in a number of experimental parameters including substantially more rapid backbone proton exchange rates, exchange-limited relaxation times and crystallographic B-factors. The stabilizing effect of the L-Trp ligand is evident in these measurements, as it is in the higher precision of the holorepressor structure.
+
The line below this paragraph, {{ABSTRACT_PUBMED_8433368}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 8433368 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_8433368}}
==About this Structure==
==About this Structure==
-
1WRT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WRT OCA].
+
1WRT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WRT OCA].
==Reference==
==Reference==
Line 27: Line 31:
[[Category: Operon repressor]]
[[Category: Operon repressor]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:03:40 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:50:18 2008''

Revision as of 15:50, 28 July 2008

Image:1wrt.png

Template:STRUCTURE 1wrt

NMR STUDY OF APO TRP REPRESSOR

Template:ABSTRACT PUBMED 8433368

About this Structure

1WRT is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

Refined solution structures of the Escherichia coli trp holo- and aporepressor., Zhao D, Arrowsmith CH, Jia X, Jardetzky O, J Mol Biol. 1993 Feb 5;229(3):735-46. PMID:8433368

Page seeded by OCA on Mon Jul 28 18:50:18 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wrt"
Personal tools