1wsa

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1wsa.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1wsa.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1wsa| PDB=1wsa | SCENE= }}
{{STRUCTURE_1wsa| PDB=1wsa | SCENE= }}
-
'''STRUCTURE OF L-ASPARAGINASE II PRECURSOR'''
+
===STRUCTURE OF L-ASPARAGINASE II PRECURSOR===
-
==Overview==
+
<!--
-
The amino acid sequence and tertiary structure of Wolinella succinogenes L-asparaginase were determined, and were compared with the structures of other type-II bacterial L-asparaginases. Each chain of this homotetrameric enzyme consists of 330 residues. The amino acid sequence is 40-50% identical to the sequences of related proteins from other bacterial sources, and all residues previously shown to be crucial for the catalytic action of these enzymes are identical. Differences between the amino acid sequence of W. succinogenes L-asparaginase and that of related enzymes are discussed in terms of the possible influence on the substrate specificity. The overall fold of the protein subunit is almost identical to that observed for other L-asparaginases. Two fragments in each subunit, a very highly flexible loop (approximately 20 amino acids) that forms part of the active site, and the N-terminus (two amino acids), are not defined in the structure. The orientation of Thr14, a residue probably involved in the catalytic activity, indicates the absence of ligand in the active-site pocket. The rigid part of the active site, which includes the asparaginase triad Thr93-Lys 166-Asp94, is structurally very highly conserved with equivalent regions found in other type-II bacterial L-asparaginases.
+
The line below this paragraph, {{ABSTRACT_PUBMED_8898907}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 8898907 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_8898907}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Periplasmic]]
[[Category: Periplasmic]]
[[Category: Signal]]
[[Category: Signal]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:04:38 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:27:43 2008''

Revision as of 06:27, 28 July 2008

Image:1wsa.png

Template:STRUCTURE 1wsa

STRUCTURE OF L-ASPARAGINASE II PRECURSOR

Template:ABSTRACT PUBMED 8898907

About this Structure

1WSA is a Single protein structure of sequence from Wolinella succinogenes. Full crystallographic information is available from OCA.

Reference

Crystal structure and amino acid sequence of Wolinella succinogenes L-asparaginase., Lubkowski J, Palm GJ, Gilliland GL, Derst C, Rohm KH, Wlodawer A, Eur J Biochem. 1996 Oct 1;241(1):201-7. PMID:8898907

Page seeded by OCA on Mon Jul 28 09:27:43 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wsa"
Personal tools