9t2h

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m (Protected "9t2h" [edit=sysop:move=sysop])
Current revision (08:23, 11 December 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9t2h is ON HOLD
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==Jumonji domain-containing protein 2B with crystallization epitope mutations L916G:R917A:A918D==
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<StructureSection load='9t2h' size='340' side='right'caption='[[9t2h]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
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Authors: Fairhead, M., Strain-Damerell, C., Ye, M., Mackinnon, S.R., Pinkas, D., MacLean, E.M., Koekemoer, L., Damerell, D., Krojer, T., Arrowsmith, C.H., Edwards, A., Bountra, C., Yue, W., Burgess-Brown, N., Marsden, B., von Delft, F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9t2h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9T2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9T2H FirstGlance]. <br>
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Description: Jumonji domain-containing protein 2B with crystallization epitope mutations L916G:R917A:A918D
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Arrowsmith, C.H]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9t2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9t2h OCA], [https://pdbe.org/9t2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9t2h RCSB], [https://www.ebi.ac.uk/pdbsum/9t2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9t2h ProSAT]</span></td></tr>
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[[Category: Krojer, T]]
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</table>
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[[Category: Maclean, E.M]]
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== Function ==
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[[Category: Burgess-Brown, N]]
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[https://www.uniprot.org/uniprot/KDM4B_HUMAN KDM4B_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref>
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[[Category: Marsden, B]]
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== References ==
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[[Category: Yue, W]]
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<references/>
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[[Category: Damerell, D]]
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__TOC__
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[[Category: Fairhead, M]]
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</StructureSection>
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[[Category: Mackinnon, S.R]]
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[[Category: Homo sapiens]]
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[[Category: Ye, M]]
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[[Category: Large Structures]]
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[[Category: Koekemoer, L]]
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[[Category: Arrowsmith CH]]
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[[Category: Von Delft, F]]
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[[Category: Bountra C]]
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[[Category: Edwards, A]]
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[[Category: Burgess-Brown N]]
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[[Category: Pinkas, D]]
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[[Category: Damerell D]]
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[[Category: Strain-Damerell, C]]
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[[Category: Edwards A]]
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[[Category: Bountra, C]]
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[[Category: Fairhead M]]
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[[Category: Koekemoer L]]
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[[Category: Krojer T]]
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[[Category: MacLean EM]]
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[[Category: Mackinnon SR]]
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[[Category: Marsden B]]
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[[Category: Pinkas D]]
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[[Category: Strain-Damerell C]]
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[[Category: Ye M]]
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[[Category: Yue W]]
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[[Category: Von Delft F]]

Current revision

Jumonji domain-containing protein 2B with crystallization epitope mutations L916G:R917A:A918D

PDB ID 9t2h

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OCA

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