9efj
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Irreversible Mcl-1/HIT2 Complex== | |
| - | + | <StructureSection load='9efj' size='340' side='right'caption='[[9efj]], [[Resolution|resolution]] 1.82Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9efj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EFJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EFJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BI3:5-{[(1R)-2,3-dihydro-1H-indene-1-carbonyl]amino}pyridin-3-yl+hydrogen+sulfate'>A1BI3</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9efj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9efj OCA], [https://pdbe.org/9efj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9efj RCSB], [https://www.ebi.ac.uk/pdbsum/9efj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9efj ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> |
| - | [[Category: Prentiss | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Assar Z]] | ||
| + | [[Category: Baggio C]] | ||
| + | [[Category: Muzzarelli KM]] | ||
| + | [[Category: Pellecchia M]] | ||
| + | [[Category: Prentiss AM]] | ||
| + | [[Category: Udompholkul P]] | ||
Revision as of 07:29, 19 November 2025
Irreversible Mcl-1/HIT2 Complex
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