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==Overview==
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{{ABSTRACT_10490030}}
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Nerve growth factor (NGF) is involved in a variety of processes involving signalling, such as cell differentiation and survival, growth cessation and apoptosis of neurons. These events are mediated by NGF as a result of binding to its two cell-surface receptors, TrkA and p75. TrkA is a receptor with tyrosine kinase activity that forms a high-affinity binding site for NGF. Of the five domains comprising its extracellular portion, the immunoglobulin-like domain proximal to the membrane (TrkA-d5 domain) is necessary and sufficient for NGF binding. Here we present the crystal structure of human NGF in complex with human TrkA-d5 at 2.2 A resolution. The ligand-receptor interface consists of two patches of similar size. One patch involves the central beta-sheet that forms the core of the homodimeric NGF molecule and the loops at the carboxy-terminal pole of TrkA-d5. The second patch comprises the amino-terminal residues of NGF, which adopt a helical conformation upon complex formation, packing against the 'ABED' sheet of TrkA-d5. The structure is consistent with results from mutagenesis experiments for all neurotrophins, and indicates that the first patch may constitute a conserved binding motif for all family members, whereas the second patch is specific for the interaction between NGF and TrkA.
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==About this Structure==
==About this Structure==
1WWW is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1WWW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb68_1.html Neurotrophins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WWW OCA].
1WWW is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1WWW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb68_1.html Neurotrophins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WWW OCA].
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==Reference==
 
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Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor., Wiesmann C, Ultsch MH, Bass SH, de Vos AM, Nature. 1999 Sep 9;401(6749):184-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10490030 10490030]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Neurotrophins]]
[[Category: Neurotrophins]]
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[[Category: Nerve growth factor]]
[[Category: Nerve growth factor]]
[[Category: Trka receptor]]
[[Category: Trka receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:14:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:06:21 2008''

Revision as of 15:06, 26 June 2008

Image:1www.png

Template:STRUCTURE 1www

NGF IN COMPLEX WITH DOMAIN 5 OF THE TRKA RECEPTOR


Template:ABSTRACT 10490030

About this Structure

1WWW is a Protein complex structure of sequences from Homo sapiens. The following page contains interesting information on the relation of 1WWW with [Neurotrophins]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:06:21 2008

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