1wxn

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{{STRUCTURE_1wxn| PDB=1wxn | SCENE= }}
{{STRUCTURE_1wxn| PDB=1wxn | SCENE= }}
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'''Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton-gated channels'''
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===Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton-gated channels===
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==Overview==
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Acid-sensing ion channels (ASIC) are proton-gated sodium channels that have been implicated in pain transduction associated with acidosis in inflamed or ischemic tissues. APETx2, a peptide toxin effector of ASIC3, has been purified from an extract of the sea anemone Anthopleura elegantissima. APETx2 is a 42-amino-acid peptide cross-linked by three disulfide bridges. Its three-dimensional structure, as determined by conventional two-dimensional 1H-NMR, consists of a compact disulfide-bonded core composed of a four-stranded beta-sheet. It belongs to the disulfide-rich all-beta structural family encompassing peptide toxins commonly found in animal venoms. The structural characteristics of APETx2 are compared with that of PcTx1, another effector of ASIC channels but specific to the ASIC1a subtype and to APETx1, a toxin structurally related to APETx2, which targets the HERG potassium channel. Structural comparisons, coupled with the analysis of the electrostatic characteristics of these various ion channel effectors, led us to suggest a putative channel interaction surface for APETx2, encompassing its N terminus together with the type I-beta turn connecting beta-strands III and IV. This basic surface (R31 and R17) is also rich in aromatic residues (Y16, F15, Y32, and F33). An additional region made of the type II'-beta turn connecting beta-strands I and II could also play a role in the specificity observed for these different ion effectors.
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(as it appears on PubMed at http://www.pubmed.gov), where 15987885 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15987885}}
==About this Structure==
==About this Structure==
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1WXN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Anthopleura_elegantissima Anthopleura elegantissima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXN OCA].
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1WXN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Anthopleura_elegantissima Anthopleura elegantissima]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXN OCA].
==Reference==
==Reference==
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[[Category: Apetx2]]
[[Category: Apetx2]]
[[Category: Asic]]
[[Category: Asic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:16:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:48:57 2008''

Revision as of 18:49, 27 July 2008

Image:1wxn.png

Template:STRUCTURE 1wxn

Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton-gated channels

Template:ABSTRACT PUBMED 15987885

About this Structure

1WXN is a Single protein structure of sequence from Anthopleura elegantissima. Full experimental information is available from OCA.

Reference

Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton-gated channels., Chagot B, Escoubas P, Diochot S, Bernard C, Lazdunski M, Darbon H, Protein Sci. 2005 Aug;14(8):2003-10. Epub 2005 Jun 29. PMID:15987885

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