1wxy

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[[Image:1wxy.gif|left|200px]]
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{{Seed}}
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[[Image:1wxy.png|left|200px]]
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{{STRUCTURE_1wxy| PDB=1wxy | SCENE= }}
{{STRUCTURE_1wxy| PDB=1wxy | SCENE= }}
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'''Crystal structure of adenosine deaminase ligated with a potent inhibitor'''
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===Crystal structure of adenosine deaminase ligated with a potent inhibitor===
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==Overview==
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Structural snapshots corresponding to various states enable elucidation of the molecular recognition mechanism of enzymes. Adenosine deaminase has two distinct conformations, an open form and a closed form, although it has so far been unclear what factors influence adaptation of the alternative conformations. Herein, we have determined the first nonligated structure as an initial state, which was the open form, and have thereby rationally deduced the molecular recognition mechanism. Inspection of the active site in the nonligated and ligated states indicated that occupancy at one of the water-binding positions in the nonligated state was highly significant in determining alternate conformations. When this position is empty, subsequent movement of Phe65 toward the space induces the closed form. On the other hand, while occupied, the overall conformation remains in the open form. This structural understanding should greatly assist structure-oriented drug design and enable control of the enzymatic activity.
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The line below this paragraph, {{ABSTRACT_PUBMED_16060665}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16060665 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16060665}}
==About this Structure==
==About this Structure==
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[[Category: Kinoshita, T.]]
[[Category: Kinoshita, T.]]
[[Category: Beta barel]]
[[Category: Beta barel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:17:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:36:06 2008''

Revision as of 03:36, 28 July 2008

Image:1wxy.png

Template:STRUCTURE 1wxy

Crystal structure of adenosine deaminase ligated with a potent inhibitor

Template:ABSTRACT PUBMED 16060665

About this Structure

1WXY is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structural basis of compound recognition by adenosine deaminase., Kinoshita T, Nakanishi I, Terasaka T, Kuno M, Seki N, Warizaya M, Matsumura H, Inoue T, Takano K, Adachi H, Mori Y, Fujii T, Biochemistry. 2005 Aug 9;44(31):10562-9. PMID:16060665

Page seeded by OCA on Mon Jul 28 06:36:06 2008

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