1wyk

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{{Seed}}
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{{STRUCTURE_1wyk| PDB=1wyk | SCENE= }}
{{STRUCTURE_1wyk| PDB=1wyk | SCENE= }}
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'''SINDBIS VIRUS CAPSID PROTEIN (114-264)'''
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===SINDBIS VIRUS CAPSID PROTEIN (114-264)===
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==Overview==
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Alphavirus budding from the plasma membrane is initiated by the specific interaction of the nucleocapsid with the cytoplasmic domain of the glycoprotein E2. It was proposed (Lee et al., Structure 4:531-541, 1996) that binding of the capsid protein residues 108 to 110 (the "N-terminal arm" residues) to a hydrophobic pocket on the surface of the neighboring capsid protein in the crystal structure mimics the binding of the E2 C-terminal residues into this pocket. In addition, structural comparisons of wild-type and mutant Sindbis virus capsid protein (SCP) and Semliki Forest virus capsid protein suggested that budding is associated with a switch between two conformations of the hydrophobic pocket. To test the proposed mechanism, SCP(114-264), which is missing the N-terminal arm, was crystallized to examine the pocket conformation when the pocket is empty. However, the pocket was occupied by dioxane molecules from the crystallization solution. The pocket conformation was the same as that when it was occupied by the N-terminal arm, demonstrating that the pocket favors binding ligands of appropriate size and shape.
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(as it appears on PubMed at http://www.pubmed.gov), where 9779796 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9779796}}
==About this Structure==
==About this Structure==
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[[Category: Sindbi]]
[[Category: Sindbi]]
[[Category: Virus]]
[[Category: Virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:18:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:35:16 2008''

Revision as of 12:35, 28 July 2008

Image:1wyk.png

Template:STRUCTURE 1wyk

SINDBIS VIRUS CAPSID PROTEIN (114-264)

Template:ABSTRACT PUBMED 9779796

About this Structure

1WYK is a Single protein structure of sequence from Sindbis virus. Full crystallographic information is available from OCA.

Reference

Probing the potential glycoprotein binding site of sindbis virus capsid protein with dioxane and model building., Lee S, Kuhn RJ, Rossmann MG, Proteins. 1998 Nov 1;33(2):311-7. PMID:9779796

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