1x11

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{{STRUCTURE_1x11| PDB=1x11 | SCENE= }}
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'''X11 PTB DOMAIN'''
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===X11 PTB DOMAIN===
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==Overview==
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The crystal structure of the phosphotyrosine-binding domain (PTB) of the X11 protein has been determined, in complex with unphosphorylated peptides corresponding to a region of beta-amyloid precursor protein (betaAPP) that is required for receptor internalization. The mode of binding to X11 of the unphosphorylated peptides, which contain an NPxY motif, resembles that of phosphorylated peptides bound to the Shc and IRS-1 PTB domains. Eight peptide residues make specific contacts with the X11 PTB domain, and they collectively achieve high affinity (KD = 0.32 microM) and specificity. These results suggest that, in contrast to the SH2 domains, the PTB domains are primarily peptide-binding domains that have, in some cases, acquired specificity for phosphorylated tyrosines.
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==About this Structure==
==About this Structure==
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[[Category: Zhang, Z.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:48:01 2008''

Revision as of 11:48, 29 July 2008

Image:1x11.png

Template:STRUCTURE 1x11

X11 PTB DOMAIN

Template:ABSTRACT PUBMED 9321393

About this Structure

1X11 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain., Zhang Z, Lee CH, Mandiyan V, Borg JP, Margolis B, Schlessinger J, Kuriyan J, EMBO J. 1997 Oct 15;16(20):6141-50. PMID:9321393

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