1x1l

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[[Image:1x1l.gif|left|200px]]
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{{Seed}}
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[[Image:1x1l.png|left|200px]]
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{{STRUCTURE_1x1l| PDB=1x1l | SCENE= }}
{{STRUCTURE_1x1l| PDB=1x1l | SCENE= }}
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'''Interaction of ERA,a GTPase protein, with the 3'minor domain of the 16S rRNA within the THERMUS THERMOPHILUS 30S subunit.'''
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===Interaction of ERA,a GTPase protein, with the 3'minor domain of the 16S rRNA within the THERMUS THERMOPHILUS 30S subunit.===
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==Overview==
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Era (E. coliRas-like protein) is a highly conserved and essential GTPase in bacteria. It binds to the 16S ribosomal RNA (rRNA) of the small (30S) ribosomal subunit, and its depletion leads to accumulation of an unprocessed precursor of the 16S rRNA. We have obtained a three-dimensional cryo-electron microscopic map of the Thermus thermophilus 30S-Era complex. Era binds in the cleft between the head and platform of the 30S subunit and locks the subunit in a conformation that is not favorable for association with the large (50S) ribosomal subunit. The RNA binding KH motif present within the C-terminal domain of Era interacts with the conserved nucleotides in the 3' region of the 16S rRNA. Furthermore, Era makes contact with several assembly elements of the 30S subunit. These observations suggest a direct involvement of Era in the assembly and maturation of the 30S subunit.
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The line below this paragraph, {{ABSTRACT_PUBMED_15866174}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15866174 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15866174}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Interaction of Era with the 30S ribosomal subunit implications for 30S subunit assembly., Sharma MR, Barat C, Wilson DN, Booth TM, Kawazoe M, Hori-Takemoto C, Shirouzu M, Yokoyama S, Fucini P, Agrawal RK, Mol Cell. 2005 Apr 29;18(3):319-29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15866174 15866174]
Interaction of Era with the 30S ribosomal subunit implications for 30S subunit assembly., Sharma MR, Barat C, Wilson DN, Booth TM, Kawazoe M, Hori-Takemoto C, Shirouzu M, Yokoyama S, Fucini P, Agrawal RK, Mol Cell. 2005 Apr 29;18(3):319-29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15866174 15866174]
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Molecular biology. Small subunit, big science., Williamson JR, Nature. 2000 Sep 21;407(6802):306-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11014170 11014170]
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Crystal structure of ERA: a GTPase-dependent cell cycle regulator containing an RNA binding motif., Chen X, Court DL, Ji X, Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8396-401. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10411886 10411886]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Sharma, M R.]]
[[Category: Sharma, M R.]]
[[Category: Interaction of era protein with the 3'minor domain of 16s rrna]]
[[Category: Interaction of era protein with the 3'minor domain of 16s rrna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:24:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:13:20 2008''

Revision as of 10:13, 27 July 2008

Image:1x1l.png

Template:STRUCTURE 1x1l

Interaction of ERA,a GTPase protein, with the 3'minor domain of the 16S rRNA within the THERMUS THERMOPHILUS 30S subunit.

Template:ABSTRACT PUBMED 15866174

About this Structure

1X1L is a Single protein structure of sequence from Escherichia coli and Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Interaction of Era with the 30S ribosomal subunit implications for 30S subunit assembly., Sharma MR, Barat C, Wilson DN, Booth TM, Kawazoe M, Hori-Takemoto C, Shirouzu M, Yokoyama S, Fucini P, Agrawal RK, Mol Cell. 2005 Apr 29;18(3):319-29. PMID:15866174

Molecular biology. Small subunit, big science., Williamson JR, Nature. 2000 Sep 21;407(6802):306-7. PMID:11014170

Crystal structure of ERA: a GTPase-dependent cell cycle regulator containing an RNA binding motif., Chen X, Court DL, Ji X, Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8396-401. PMID:10411886

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