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1x1z

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[[Image:1x1z.gif|left|200px]]
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{{Seed}}
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[[Image:1x1z.png|left|200px]]
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{{STRUCTURE_1x1z| PDB=1x1z | SCENE= }}
{{STRUCTURE_1x1z| PDB=1x1z | SCENE= }}
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'''Orotidine 5'-monophosphate decarboxylase (odcase) complexed with BMP (produced from 6-cyanoump)'''
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===Orotidine 5'-monophosphate decarboxylase (odcase) complexed with BMP (produced from 6-cyanoump)===
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==Overview==
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Orotidine-5'-monophosphate decarboxylase (ODCase) has evolved to catalyze a decarboxylation reaction, most probably via a carbanion species at the C6 position of orotidine-5'-monophosphate. We reveal an unusual biochemical pathway of conversion of 6-cyano-uridine-5'-monophosphate by ODCase to barbiturate-5'-monophosphate via perhaps an electrophilic center at the C6 position, leading to inhibition. This potential of ODCase is very useful in the design of novel inhibitors.
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(as it appears on PubMed at http://www.pubmed.gov), where 16248642 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16248642}}
==About this Structure==
==About this Structure==
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[[Category: Wei, L.]]
[[Category: Wei, L.]]
[[Category: 6-cyanoump]]
[[Category: 6-cyanoump]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:25:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:24:59 2008''

Revision as of 20:25, 27 July 2008

Image:1x1z.png

Template:STRUCTURE 1x1z

Orotidine 5'-monophosphate decarboxylase (odcase) complexed with BMP (produced from 6-cyanoump)

Template:ABSTRACT PUBMED 16248642

About this Structure

1X1Z is a Single protein structure of sequence from Methanothermobacter thermautotrophicus. Full crystallographic information is available from OCA.

Reference

An unprecedented twist to ODCase catalytic activity., Fujihashi M, Bello AM, Poduch E, Wei L, Annedi SC, Pai EF, Kotra LP, J Am Chem Soc. 2005 Nov 2;127(43):15048-50. PMID:16248642

Page seeded by OCA on Sun Jul 27 23:24:59 2008

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