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9xv1

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Current revision (05:31, 24 December 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9xv1 is ON HOLD until Paper Publication
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==Crystal Structure of Fructose-1,6-bisphosphatase Complexed with a Covalent Inhibitor==
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<StructureSection load='9xv1' size='340' side='right'caption='[[9xv1]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
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Authors: Cao, H., Huang, Z., Hu, X., Li, W., Chang, M., Zhang, Y., Chu, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9xv1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9XV1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9XV1 FirstGlance]. <br>
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Description: Crystal Structure of Fructose-1,6-bisphosphatase Complexed with a Covalent Inhibitor
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1E1G:2-bromanyl-~{N}-[2-[4-[(3-phenylphenyl)carbamoylsulfamoyl]phenyl]ethyl]ethanamide'>A1E1G</scene></td></tr>
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[[Category: Cao, H]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9xv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9xv1 OCA], [https://pdbe.org/9xv1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9xv1 RCSB], [https://www.ebi.ac.uk/pdbsum/9xv1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9xv1 ProSAT]</span></td></tr>
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[[Category: Huang, Z]]
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</table>
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[[Category: Li, W]]
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== Disease ==
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[[Category: Hu, X]]
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[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[https://omim.org/entry/229700 229700]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref>
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[[Category: Chu, Y]]
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== Function ==
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[[Category: Chang, M]]
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[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN]
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[[Category: Zhang, Y]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Cao H]]
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[[Category: Chang M]]
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[[Category: Chu Y]]
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[[Category: Hu X]]
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[[Category: Huang Z]]
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[[Category: Li W]]
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[[Category: Zhang Y]]

Current revision

Crystal Structure of Fructose-1,6-bisphosphatase Complexed with a Covalent Inhibitor

PDB ID 9xv1

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