1x71

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{{STRUCTURE_1x71| PDB=1x71 | SCENE= }}
{{STRUCTURE_1x71| PDB=1x71 | SCENE= }}
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'''Crystal structure of Siderocalin (NGAL, Lipocalin 2) complexed with TRENCAM-3,2-HOPO, a cepabactin analogue'''
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===Crystal structure of Siderocalin (NGAL, Lipocalin 2) complexed with TRENCAM-3,2-HOPO, a cepabactin analogue===
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==Overview==
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Siderocalin, a member of the lipocalin family of binding proteins, is found in neutrophil granules, uterine secretions, and at markedly elevated levels in serum and synovium during bacterial infection; it is also secreted from epithelial cells in response to inflammation or tumorigenesis. Identification of high-affinity ligands, bacterial catecholate-type siderophores (such as enterochelin), suggested a possible function for siderocalin: an antibacterial agent, complementing the general antimicrobial innate immune system iron-depletion strategy, sequestering iron as ferric siderophore complexes. Supporting this hypothesis, siderocalin is a potent bacteriostatic agent in vitro under iron-limiting conditions and, when knocked out, renders mice remarkably susceptible to bacterial infection. Here we show that siderocalin also binds soluble siderophores of mycobacteria, including M. tuberculosis: carboxymycobactins. Siderocalin employs a degenerate recognition mechanism to cross react with these dissimilar types of siderophores, broadening the potential utility of this innate immune defense.
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(as it appears on PubMed at http://www.pubmed.gov), where 15642259 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15642259}}
==About this Structure==
==About this Structure==
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[[Category: Lipocalin]]
[[Category: Lipocalin]]
[[Category: Siderophore]]
[[Category: Siderophore]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:38:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:32:02 2008''

Revision as of 23:32, 28 July 2008

Image:1x71.png

Template:STRUCTURE 1x71

Crystal structure of Siderocalin (NGAL, Lipocalin 2) complexed with TRENCAM-3,2-HOPO, a cepabactin analogue

Template:ABSTRACT PUBMED 15642259

About this Structure

1X71 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Siderocalin (Lcn 2) also binds carboxymycobactins, potentially defending against mycobacterial infections through iron sequestration., Holmes MA, Paulsene W, Jide X, Ratledge C, Strong RK, Structure. 2005 Jan;13(1):29-41. PMID:15642259

Page seeded by OCA on Tue Jul 29 02:32:02 2008

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