This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1x8b

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1x8b.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1x8b.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1x8b| PDB=1x8b | SCENE= }}
{{STRUCTURE_1x8b| PDB=1x8b | SCENE= }}
-
'''Structure of human Wee1A kinase: kinase domain complexed with inhibitor PD0407824'''
+
===Structure of human Wee1A kinase: kinase domain complexed with inhibitor PD0407824===
-
==Overview==
+
<!--
-
Phosphorylation is critical to regulation of the eukaryotic cell cycle. Entry to mitosis is triggered by the cyclin-dependent kinase CDK1 (Cdc2), which is inactivated during the preceding S and G2 phases by phosphorylation of T14 and Y15. Two homologous kinases, Wee1, which phosphorylates Y15, and Myt1, which phosphorylates both T14 and Y15, mediate this inactivation. We have determined the crystal structure of the catalytic domain of human somatic Wee1 (Wee1A) complexed with an active-site inhibitor at 1.8 A resolution. Although Wee1A is functionally a tyrosine kinase, in sequence and structure it most closely resembles serine/threonine kinases such as Chk1 and cAMP kinases. The crystal structure shows that although the catalytic site closely resembles that of other protein kinases, the activation segment contains Wee1-specific features that maintain it in an active conformation and, together with a key substitution in its glycine-rich loop, help determine its substrate specificity.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15837193}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15837193 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15837193}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Kinase]]
[[Category: Kinase]]
[[Category: Wee1]]
[[Category: Wee1]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:41:49 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:21:00 2008''

Revision as of 23:21, 27 July 2008

Image:1x8b.png

Template:STRUCTURE 1x8b

Structure of human Wee1A kinase: kinase domain complexed with inhibitor PD0407824

Template:ABSTRACT PUBMED 15837193

About this Structure

1X8B is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation., Squire CJ, Dickson JM, Ivanovic I, Baker EN, Structure. 2005 Apr;13(4):541-50. PMID:15837193

Page seeded by OCA on Mon Jul 28 02:21:00 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1x8b"
Personal tools