1x9y

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[[Image:1x9y.gif|left|200px]]
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{{Seed}}
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[[Image:1x9y.png|left|200px]]
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{{STRUCTURE_1x9y| PDB=1x9y | SCENE= }}
{{STRUCTURE_1x9y| PDB=1x9y | SCENE= }}
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'''The prostaphopain B structure'''
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===The prostaphopain B structure===
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==Overview==
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Prostaphopain B is the precursor of staphopain B, a papain-type secreted cysteine protease from the pathogen Staphylococcus aureus. Here, we describe the 2.5 A crystal structure of the proenzyme. Its 21 kDa proregion is organized around a central half-barrel or barrel-sandwich hybrid and occludes primed, but not nonprimed, sites in the active site cleft of the protease. The structure of the mature part of the protease is similar to previously reported staphopain structures, and no distortion of the catalytic residues is apparent at 2.5 A resolution. A comparison of prostaphopain B with the staphopain B-staphostatin B complex shows that the proregion and the inhibitor interact with largely nonoverlapping parts of the protease surface. In a modeled complex of prostaphopain B with staphostatin B, clashes occur both inside and outside the active site cleft, but involve mostly poorly ordered regions of the protein that may be mobile.
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(as it appears on PubMed at http://www.pubmed.gov), where 15518582 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15518582}}
==About this Structure==
==About this Structure==
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[[Category: Barrel-sandwich-hybrid]]
[[Category: Barrel-sandwich-hybrid]]
[[Category: Half-barrel]]
[[Category: Half-barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:04:05 2008''

Revision as of 11:04, 29 July 2008

Image:1x9y.png

Template:STRUCTURE 1x9y

The prostaphopain B structure

Template:ABSTRACT PUBMED 15518582

About this Structure

1X9Y is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Prostaphopain B structure: a comparison of proregion-mediated and staphostatin-mediated protease inhibition., Filipek R, Szczepanowski R, Sabat A, Potempa J, Bochtler M, Biochemistry. 2004 Nov 9;43(44):14306-15. PMID:15518582

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