1xak

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{{STRUCTURE_1xak| PDB=1xak | SCENE= }}
{{STRUCTURE_1xak| PDB=1xak | SCENE= }}
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'''STRUCTURE OF THE SARS-CORONAVIRUS ORF7A ACCESSORY PROTEIN'''
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===STRUCTURE OF THE SARS-CORONAVIRUS ORF7A ACCESSORY PROTEIN===
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==Overview==
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The open reading frame (ORF) 7a of the SARS-associated coronavirus (SARS-CoV) encodes a unique type I transmembrane protein of unknown function. We have determined the 1.8 A resolution crystal structure of the N-terminal ectodomain of orf7a, revealing a compact seven-stranded beta sandwich unexpectedly similar in fold and topology to members of the Ig superfamily. We also demonstrate that, in SARS-CoV- infected cells, the orf7a protein is expressed and retained intracellularly. Confocal microscopy studies using orf7a and orf7a/CD4 chimeras implicate the short cytoplasmic tail and transmembrane domain in trafficking of the protein within the endoplasmic reticulum and Golgi network. Taken together, our findings provide a structural and cellular framework in which to explore the role of orf7a in SARS-CoV pathogenesis.
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(as it appears on PubMed at http://www.pubmed.gov), where 15642263 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15642263}}
==About this Structure==
==About this Structure==
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[[Category: Psi]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:47:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:08:37 2008''

Revision as of 17:08, 28 July 2008

Image:1xak.png

Template:STRUCTURE 1xak

STRUCTURE OF THE SARS-CORONAVIRUS ORF7A ACCESSORY PROTEIN

Template:ABSTRACT PUBMED 15642263

About this Structure

1XAK is a Single protein structure of sequence from Human sars coronavirus. Full crystallographic information is available from OCA.

Reference

Structure and intracellular targeting of the SARS-coronavirus Orf7a accessory protein., Nelson CA, Pekosz A, Lee CA, Diamond MS, Fremont DH, Structure. 2005 Jan;13(1):75-85. PMID:15642263

Page seeded by OCA on Mon Jul 28 20:08:37 2008

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