1xbo

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{{STRUCTURE_1xbo| PDB=1xbo | SCENE= }}
{{STRUCTURE_1xbo| PDB=1xbo | SCENE= }}
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'''PTP1B complexed with Isoxazole Carboxylic Acid'''
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===PTP1B complexed with Isoxazole Carboxylic Acid===
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==Overview==
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Guided by X-ray crystallography, we have extended the structure-activity relationship (SAR) study on an isoxazole carboxylic acid-based PTP1B inhibitor (1) and more potent and equally selective (&gt;20-fold selectivity over the highly homologous T-cell PTPase, TCPTP) PTP1B inhibitors were identified. Inhibitor 7 demonstrated good cellular activity against PTP1B in COS 7 cells.
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{{ABSTRACT_PUBMED_15482920}}
==About this Structure==
==About this Structure==
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[[Category: Protein tyrosine phosphatase 1b]]
[[Category: Protein tyrosine phosphatase 1b]]
[[Category: Ptp1b]]
[[Category: Ptp1b]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:49:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:59:52 2008''

Revision as of 19:00, 27 July 2008

Image:1xbo.png

Template:STRUCTURE 1xbo

PTP1B complexed with Isoxazole Carboxylic Acid

Template:ABSTRACT PUBMED 15482920

About this Structure

1XBO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors., Zhao H, Liu G, Xin Z, Serby MD, Pei Z, Szczepankiewicz BG, Hajduk PJ, Abad-Zapatero C, Hutchins CW, Lubben TH, Ballaron SJ, Haasch DL, Kaszubska W, Rondinone CM, Trevillyan JM, Jirousek MR, Bioorg Med Chem Lett. 2004 Nov 15;14(22):5543-6. PMID:15482920

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