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1xcs

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{{STRUCTURE_1xcs| PDB=1xcs | SCENE= }}
{{STRUCTURE_1xcs| PDB=1xcs | SCENE= }}
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'''structure of oligonucleotide/drug complex'''
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===structure of oligonucleotide/drug complex===
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==Overview==
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The crystal structures of the hexamer duplex d(CGTACG)(2) complexed with the intercalating anthraquinone derivative 1,5-bis[3-(diethylamino)propionamido]anthracene-9,10-dione and the acridine derivative 9-acridinyl tetralysine have been solved at 2.0- and 1.4-A resolution, respectively. In both cases, the drugs adopt multiple orientations within a large DNA cavity constituted by two groups of four approximately coplanar bases. Cations play a pivotal role in the crystal structure. Both complexes crystallise in the presence of Co(2+), Ba(2+) and Na(+) ions. They reveal at least two different types of coordination environments: (1) specific sites for Co(2+) interacting with N7 of guanine; (2) a central ionic site formed by four phosphate groups, which can be occupied by different ions. One more ionic site that is not always occupied by ions is also visible in the electron density map. All of them play a role in the crystal structure.
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The line below this paragraph, {{ABSTRACT_PUBMED_15926069}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15926069 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15926069}}
==About this Structure==
==About this Structure==
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[[Category: Double helix]]
[[Category: Double helix]]
[[Category: Drug-dna complex]]
[[Category: Drug-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:51:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:44:54 2008''

Revision as of 15:44, 28 July 2008

Image:1xcs.gif

Template:STRUCTURE 1xcs

structure of oligonucleotide/drug complex

Template:ABSTRACT PUBMED 15926069

About this Structure

Full crystallographic information is available from OCA.

Reference

Variable role of ions in two drug intercalation complexes of DNA., Valls N, Steiner RA, Wright G, Murshudov GN, Subirana JA, J Biol Inorg Chem. 2005 Aug;10(5):476-82. Epub 2005 Sep 23. PMID:15926069

Page seeded by OCA on Mon Jul 28 18:44:54 2008

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