1xd4

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{{STRUCTURE_1xd4| PDB=1xd4 | SCENE= }}
{{STRUCTURE_1xd4| PDB=1xd4 | SCENE= }}
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'''Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS)'''
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===Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS)===
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==Overview==
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The classical model for the activation of the nucleotide exchange factor Son of sevenless (SOS) involves its recruitment to the membrane, where it engages Ras. The recent discovery that Ras*GTP is an allosteric activator of SOS indicated that the regulation of SOS is more complex than originally envisaged. We now present crystallographic and biochemical analyses of a construct of SOS that contains the Dbl homology-pleckstrin homology (DH-PH) and catalytic domains and show that the DH-PH unit blocks the allosteric binding site for Ras and suppresses the activity of SOS. SOS is dependent on Ras binding to the allosteric site for both a lower level of activity, which is a result of Ras*GDP binding, and maximal activity, which requires Ras*GTP. The action of the DH-PH unit gates a reciprocal interaction between Ras and SOS, in which Ras converts SOS from low to high activity forms as Ras*GDP is converted to Ras*GTP by SOS.
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(as it appears on PubMed at http://www.pubmed.gov), where 15507210 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15507210}}
==Disease==
==Disease==
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[[Category: Nucleotide exchange factor]]
[[Category: Nucleotide exchange factor]]
[[Category: Ra]]
[[Category: Ra]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:52:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:44:10 2008''

Revision as of 04:44, 28 July 2008

Image:1xd4.png

Template:STRUCTURE 1xd4

Contents

Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS)

Template:ABSTRACT PUBMED 15507210

Disease

Known disease associated with this structure: Fibromatosis, gingival OMIM:[182530], Noonan syndrome 4 OMIM:[182530]

About this Structure

1XD4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural analysis of autoinhibition in the Ras activator Son of sevenless., Sondermann H, Soisson SM, Boykevisch S, Yang SS, Bar-Sagi D, Kuriyan J, Cell. 2004 Oct 29;119(3):393-405. PMID:15507210

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