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1xe0

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{{STRUCTURE_1xe0| PDB=1xe0 | SCENE= }}
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'''The structure and function of Xenopus NO38-core, a histone binding chaperone in the nucleolus'''
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===The structure and function of Xenopus NO38-core, a histone binding chaperone in the nucleolus===
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==Overview==
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Xenopus NO38 is an abundant nucleolar chaperone and a member of the nucleoplasmin (Np) family. Here, we report high-resolution crystal structures of the N-terminal domain of NO38, as a pentamer and a decamer. As expected, NO38 shares the Np family fold. In addition, NO38- and Np-core pentamers each use highly conserved residues and numerous waters to form their respective decamers. Further studies show that NO38 and Np each bind equal amounts of the four core histones. However, NO38 prefers the (H3-H4)(2) tetramer, while Np probably prefers H2A-H2B dimers. We also show that NO38 and Np will each bind noncognate histones when the preferred partner is absent. We suggest that these chaperones must form decamers in order to bind histones and differentiate between histone tetramers and dimers. When taken together, these data imply that NO38 may function as a histone chaperone in the nucleolus.
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{{ABSTRACT_PUBMED_15576029}}
==About this Structure==
==About this Structure==
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[[Category: No38]]
[[Category: No38]]
[[Category: X-ray crystallography]]
[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:54:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:26:18 2008''

Revision as of 11:26, 28 July 2008

Image:1xe0.png

Template:STRUCTURE 1xe0

The structure and function of Xenopus NO38-core, a histone binding chaperone in the nucleolus

Template:ABSTRACT PUBMED 15576029

About this Structure

1XE0 is a Single protein structure of sequence from Xenopus laevis. Full crystallographic information is available from OCA.

Reference

The structure and function of Xenopus NO38-core, a histone chaperone in the nucleolus., Namboodiri VM, Akey IV, Schmidt-Zachmann MS, Head JF, Akey CW, Structure. 2004 Dec;12(12):2149-60. PMID:15576029

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