We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1xee

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1xee.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1xee.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1xee| PDB=1xee | SCENE= }}
{{STRUCTURE_1xee| PDB=1xee | SCENE= }}
-
'''Solution structure of the Chemotaxis Inhibitory Protein of Staphylococcus aureus'''
+
===Solution structure of the Chemotaxis Inhibitory Protein of Staphylococcus aureus===
-
==Overview==
+
<!--
-
The chemotaxis inhibitory protein of Staphylococcus aureus (CHIPS) is a 121 residue excreted virulence factor. It acts by binding the C5a- (C5aR) and formylated peptide receptor (FPR) and thereby blocks specific phagocyte responses. Here, we report the solution structure of a CHIPS fragment consisting of residues 31-121 (CHIPS31-121). CHIPS31-121 has the same activity in blocking the C5aR compared to full-length CHIPS, but completely lacks FPR antagonism. CHIPS31-121 has a compact fold comprising an alpha-helix (residues 38-51) packed onto a four-stranded anti-parallel beta-sheet. Strands beta2 and beta3 are joined by a long loop with a relatively well-defined conformation. Comparison of CHIPS31-121 with known structures reveals striking homology with the C-terminal domain of staphylococcal superantigen-like proteins (SSLs) 5 and 7, and the staphyloccocal and streptococcal superantigens TSST-1 and SPE-C. Also, the recently reported structures of several domains of the staphylococcal extracellullar adherence protein (EAP) show a high degree of structural similarity with CHIPS. Most of the conserved residues in CHIPS and its structural homologues are present in the alpha-helix. A conserved arginine residue (R46 in CHIPS) appears to be involved in preservation of the structure. Site-directed mutagenesis of all positively charged residues in CHIPS31-121 reveals a major involvement of arginine 44 and lysine 95 in C5aR antagonism. The structure of CHIPS31-121 will be vital in the further unraveling of its precise mechanism of action. Its structural homology to S.aureus SSLs, superantigens, and EAP might help the design of future experiments towards an understanding of the relationship between structure and function of these proteins.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16213522}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16213522 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16213522}}
==About this Structure==
==About this Structure==
-
1XEE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEE OCA].
+
1XEE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEE OCA].
==Reference==
==Reference==
Line 37: Line 41:
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Superantigen]]
[[Category: Superantigen]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:55:23 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:09:26 2008''

Revision as of 22:09, 27 July 2008

Image:1xee.png

Template:STRUCTURE 1xee

Solution structure of the Chemotaxis Inhibitory Protein of Staphylococcus aureus

Template:ABSTRACT PUBMED 16213522

About this Structure

1XEE is a Single protein structure of sequence from Staphylococcus aureus. Full experimental information is available from OCA.

Reference

The structure of the C5a receptor-blocking domain of chemotaxis inhibitory protein of Staphylococcus aureus is related to a group of immune evasive molecules., Haas PJ, de Haas CJ, Poppelier MJ, van Kessel KP, van Strijp JA, Dijkstra K, Scheek RM, Fan H, Kruijtzer JA, Liskamp RM, Kemmink J, J Mol Biol. 2005 Nov 4;353(4):859-72. Epub 2005 Sep 23. PMID:16213522

Page seeded by OCA on Mon Jul 28 01:09:26 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xee"
Personal tools