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1xgu

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[[Image:1xgu.gif|left|200px]]
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{{Seed}}
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[[Image:1xgu.png|left|200px]]
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{{STRUCTURE_1xgu| PDB=1xgu | SCENE= }}
{{STRUCTURE_1xgu| PDB=1xgu | SCENE= }}
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'''Structure for antibody HyHEL-63 Y33F mutant complexed with hen egg lysozyme'''
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===Structure for antibody HyHEL-63 Y33F mutant complexed with hen egg lysozyme===
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==Overview==
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Hydrophobic interactions are essential for stabilizing protein-protein complexes, whose interfaces generally consist of a central cluster of hot spot residues surrounded by less important peripheral residues. According to the O-ring hypothesis, a condition for high affinity binding is solvent exclusion from interacting residues. This hypothesis predicts that the hydrophobicity at the center is significantly greater than at the periphery, which we estimated at 21 cal mol(-1) A(-2). To measure the hydrophobicity at the center, structures of an antigen-antibody complex where a buried phenylalanine was replaced by smaller hydrophobic residues were determined. By correlating structural changes with binding free energies, we estimate the hydrophobicity at this central site to be 46 cal mol(-1) A(-2), twice that at the periphery. This context dependence of the hydrophobic effect explains the clustering of hot spots at interface centers and has implications for hot spot prediction and the design of small molecule inhibitors.
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The line below this paragraph, {{ABSTRACT_PUBMED_15698573}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15698573 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15698573}}
==About this Structure==
==About this Structure==
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[[Category: Hyhel-63]]
[[Category: Hyhel-63]]
[[Category: Y33f mutant]]
[[Category: Y33f mutant]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:00:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:52:32 2008''

Revision as of 03:52, 28 July 2008

Image:1xgu.png

Template:STRUCTURE 1xgu

Structure for antibody HyHEL-63 Y33F mutant complexed with hen egg lysozyme

Template:ABSTRACT PUBMED 15698573

About this Structure

Full crystallographic information is available from OCA.

Reference

Magnitude of the hydrophobic effect at central versus peripheral sites in protein-protein interfaces., Li Y, Huang Y, Swaminathan CP, Smith-Gill SJ, Mariuzza RA, Structure. 2005 Feb;13(2):297-307. PMID:15698573

Page seeded by OCA on Mon Jul 28 06:52:32 2008

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