1xiw

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{{STRUCTURE_1xiw| PDB=1xiw | SCENE= }}
{{STRUCTURE_1xiw| PDB=1xiw | SCENE= }}
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'''Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment'''
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===Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment===
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==Overview==
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The alpha/beta T cell receptor complex transmits signals from MHC/peptide antigens through a set of constitutively associated signaling molecules, including CD3-epsilon/gamma and CD3-epsilon/delta. We report the crystal structure at 1.9-A resolution of a complex between a human CD3-epsilon/delta ectodomain heterodimer and a single-chain fragment of the UCHT1 antibody. CD3-epsilon/delta and CD3-epsilon/gamma share a conserved interface between the Ig-fold ectodomains, with parallel packing of the two G strands. CD3-delta has a more electronegative surface and a more compact Ig fold than CD3-gamma; thus, the two CD3 heterodimers have distinctly different molecular surfaces. The UCHT1 antibody binds near an acidic region of CD3-epsilon opposite the dimer interface, occluding this region from direct interaction with the TCR. This immunodominant epitope may be a uniquely accessible surface in the TCR/CD3 complex, because there is overlap between the binding site of the UCHT1 and OKT3 antibodies. Determination of the CD3-epsilon/delta structure completes the set of TCR/CD3 globular ectodomains and contributes information about exposed CD3 surfaces.
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The line below this paragraph, {{ABSTRACT_PUBMED_15534202}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15534202 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15534202}}
==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
[[Category: Ucht1-scfv]]
[[Category: Ucht1-scfv]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:05:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:27:12 2008''

Revision as of 15:27, 27 July 2008

Image:1xiw.png

Template:STRUCTURE 1xiw

Crystal structure of human CD3-e/d dimer in complex with a UCHT1 single-chain antibody fragment

Template:ABSTRACT PUBMED 15534202

About this Structure

1XIW is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment., Arnett KL, Harrison SC, Wiley DC, Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16268-73. Epub 2004 Nov 8. PMID:15534202

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