1xj7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1xj7.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1xj7.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1xj7| PDB=1xj7 | SCENE= }}
{{STRUCTURE_1xj7| PDB=1xj7 | SCENE= }}
-
'''Complex Androgen Receptor LBD and RAC3 peptide'''
+
===Complex Androgen Receptor LBD and RAC3 peptide===
-
==Overview==
+
<!--
-
Androgens drive sex differentiation, bone and muscle development, and promote growth of hormone-dependent cancers by binding the nuclear androgen receptor (AR), which recruits coactivators to responsive genes. Most nuclear receptors recruit steroid receptor coactivators (SRCs) to their ligand binding domain (LBD) using a leucine-rich motif (LXXLL). AR is believed to recruit unique coactivators to its LBD using an aromatic-rich motif (FXXLF) while recruiting SRCs to its N-terminal domain (NTD) through an alternate mechanism. Here, we report that the AR-LBD interacts with both FXXLF motifs and a subset of LXXLL motifs and that contacts with these LXXLL motifs are both necessary and sufficient for SRC-mediated AR regulation of transcription. Crystal structures of the activated AR in complex with both recruitment motifs reveal that side chains unique to the AR-LBD rearrange to bind either the bulky FXXLF motifs or the more compact LXXLL motifs and that AR utilizes subsidiary contacts with LXXLL flanking sequences to discriminate between LXXLL motifs.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15563469}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15563469 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15563469}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Webb, P.]]
[[Category: Webb, P.]]
[[Category: Androgen receptor coactivators lxxll motif]]
[[Category: Androgen receptor coactivators lxxll motif]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:06:01 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:47:40 2008''

Revision as of 02:47, 29 July 2008

Image:1xj7.png

Template:STRUCTURE 1xj7

Complex Androgen Receptor LBD and RAC3 peptide

Template:ABSTRACT PUBMED 15563469

About this Structure

1XJ7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor., Estebanez-Perpina E, Moore JM, Mar E, Delgado-Rodrigues E, Nguyen P, Baxter JD, Buehrer BM, Webb P, Fletterick RJ, Guy RK, J Biol Chem. 2005 Mar 4;280(9):8060-8. Epub 2004 Nov 24. PMID:15563469

Page seeded by OCA on Tue Jul 29 05:47:40 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xj7"
Personal tools