1xm2

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{{STRUCTURE_1xm2| PDB=1xm2 | SCENE= }}
{{STRUCTURE_1xm2| PDB=1xm2 | SCENE= }}
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'''Crystal structure of Human PRL-1'''
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===Crystal structure of Human PRL-1===
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==Overview==
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The PRL phosphatases, which constitute a subfamily of the protein tyrosine phosphatases (PTPs), are implicated in oncogenic and metastatic processes. Here, we report the crystal structure of human PRL-1 determined at 2.7A resolution. The crystal structure reveals the shallow active-site pocket with highly hydrophobic character. A structural comparison with the previously determined NMR structure of PRL-3 exhibits significant differences in the active-site region. In the PRL-1 structure, a sulfate ion is bound to the active-site, providing stabilizing interactions to maintain the canonically found active conformation of PTPs, whereas the NMR structure exhibits an open conformation of the active-site. We also found that PRL-1 forms a trimer in the crystal and the trimer exists in the membrane fraction of cells, suggesting the possible biological regulation of PRL-1 activity by oligomerization. The detailed structural information on the active enzyme conformation and regulation of PRL-1 provides the structural basis for the development of potential inhibitors of PRL enzymes.
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{{ABSTRACT_PUBMED_15571731}}
==About this Structure==
==About this Structure==
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[[Category: Son, J H.]]
[[Category: Son, J H.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:12:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:30:03 2008''

Revision as of 05:30, 28 July 2008

Image:1xm2.png

Template:STRUCTURE 1xm2

Crystal structure of Human PRL-1

Template:ABSTRACT PUBMED 15571731

About this Structure

1XM2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms., Jeong DG, Kim SJ, Kim JH, Son JH, Park MR, Lim SM, Yoon TS, Ryu SE, J Mol Biol. 2005 Jan 14;345(2):401-13. PMID:15571731

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