1xoe

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[[Image:1xoe.gif|left|200px]]
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{{Seed}}
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[[Image:1xoe.png|left|200px]]
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{{STRUCTURE_1xoe| PDB=1xoe | SCENE= }}
{{STRUCTURE_1xoe| PDB=1xoe | SCENE= }}
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'''N9 Tern influenza neuraminidase complexed with (2R,4R,5R)-5-(1-Acetylamino-3-methyl-butyl-pyrrolidine-2, 4-dicarobyxylic acid 4-methyl esterdase complexed with'''
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===N9 Tern influenza neuraminidase complexed with (2R,4R,5R)-5-(1-Acetylamino-3-methyl-butyl-pyrrolidine-2, 4-dicarobyxylic acid 4-methyl esterdase complexed with===
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==Overview==
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(+/-)-(2R,3R,5R)-[2-(1'-S-acetamido-3'-methyl)butyl-3-methoxycarbonyl]tetr ahydrofuran-5-carboxylic acid (9) and (+/-)-(2R,3R,5R)-[2-(1'-S-acetamido-3'-methyl)butyl-3-(4'-imidazolyl)]tetr ahydrofuran 5-carboxylic acid (14) were synthesized as inhibitors of influenza neuraminidase (NA). Both compounds 9 and 14 inhibit influenza NA A with an IC(50) of about 0.5 microM and NA B with an IC(50) of 1.0 microM.
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The line below this paragraph, {{ABSTRACT_PUBMED_15582424}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15582424 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15582424}}
==About this Structure==
==About this Structure==
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[[Category: Neuraminidase]]
[[Category: Neuraminidase]]
[[Category: Pyrrolidine inhibitor]]
[[Category: Pyrrolidine inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:17:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:34:38 2008''

Revision as of 19:34, 27 July 2008

Image:1xoe.png

Template:STRUCTURE 1xoe

N9 Tern influenza neuraminidase complexed with (2R,4R,5R)-5-(1-Acetylamino-3-methyl-butyl-pyrrolidine-2, 4-dicarobyxylic acid 4-methyl esterdase complexed with

Template:ABSTRACT PUBMED 15582424

About this Structure

1XOE is a Single protein structure of sequence from Influenza a virus. Full crystallographic information is available from OCA.

Reference

Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core., Wang GT, Wang S, Gentles R, Sowin T, Maring CJ, Kempf DJ, Kati WM, Stoll V, Stewart KD, Laver G, Bioorg Med Chem Lett. 2005 Jan 3;15(1):125-8. PMID:15582424

Page seeded by OCA on Sun Jul 27 22:34:38 2008

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