1xoi

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[[Image:1xoi.gif|left|200px]]
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{{STRUCTURE_1xoi| PDB=1xoi | SCENE= }}
{{STRUCTURE_1xoi| PDB=1xoi | SCENE= }}
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'''Human Liver Glycogen Phosphorylase A complexed with Chloroindoloyl glycine amide'''
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===Human Liver Glycogen Phosphorylase A complexed with Chloroindoloyl glycine amide===
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==Overview==
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The synthesis, in vitro, and in vivo biological characterization of a series of achiral 5-chloroindoloyl glycine amide inhibitors of human liver glycogen phosphorylase A are described. Improved potency over previously reported compounds in cellular and in vivo assays was observed. The allosteric binding site of these compounds was shown by X-ray crystallography to be the same as that reported previously for 5-chloroindoloyl norstatine amides.
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(as it appears on PubMed at http://www.pubmed.gov), where 15603973 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15603973}}
==About this Structure==
==About this Structure==
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[[Category: Glycogen storage disease]]
[[Category: Glycogen storage disease]]
[[Category: Glycosyltransferase]]
[[Category: Glycosyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:17:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:25:01 2008''

Revision as of 03:25, 29 July 2008

Image:1xoi.png

Template:STRUCTURE 1xoi

Human Liver Glycogen Phosphorylase A complexed with Chloroindoloyl glycine amide

Template:ABSTRACT PUBMED 15603973

About this Structure

1XOI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase: synthesis, in vitro, in vivo, and X-ray crystallographic characterization., Wright SW, Rath VL, Genereux PE, Hageman DL, Levy CB, McClure LD, McCoid SC, McPherson RK, Schelhorn TM, Wilder DE, Zavadoski WJ, Gibbs EM, Treadway JL, Bioorg Med Chem Lett. 2005 Jan 17;15(2):459-65. PMID:15603973

Page seeded by OCA on Tue Jul 29 06:25:01 2008

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