1xph

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[[Image:1xph.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1xph| PDB=1xph | SCENE= }}
{{STRUCTURE_1xph| PDB=1xph | SCENE= }}
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'''Structure of DC-SIGNR and a portion of repeat domain 8'''
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===Structure of DC-SIGNR and a portion of repeat domain 8===
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==Overview==
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The dendritic cell-specific ICAM-3 non-integrin (DC-SIGN) and its close relative DC-SIGNR recognize various glycoproteins, both pathogenic and cellular, through the receptor lectin domain-mediated carbohydrate recognition. While the carbohydrate-recognition domains (CRD) exist as monomers and bind individual carbohydrates with low affinity and are permissive in nature, the full-length receptors form tetramers through their repeat domain and recognize specific ligands with high affinity. To understand the tetramer-based ligand binding avidity, we determined the crystal structure of DC-SIGNR with its last repeat region. Compared to the carbohydrate-bound CRD structure, the structure revealed conformational changes in the calcium and carbohydrate coordination loops of CRD, an additional disulfide bond between the N and the C termini of the CRD, and a helical conformation for the last repeat. On the basis of the current crystal structure and other published structures with sequence homology to the repeat domain, we generated a tetramer model for DC-SIGN/R using homology modeling and propose a ligand-recognition index to identify potential receptor ligands.
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The line below this paragraph, {{ABSTRACT_PUBMED_15784257}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15784257 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15784257}}
==About this Structure==
==About this Structure==
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[[Category: Carbohydrate recognition domain]]
[[Category: Carbohydrate recognition domain]]
[[Category: Repeat domain]]
[[Category: Repeat domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:20:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:19:18 2008''

Revision as of 11:19, 27 July 2008

Image:1xph.png

Template:STRUCTURE 1xph

Structure of DC-SIGNR and a portion of repeat domain 8

Template:ABSTRACT PUBMED 15784257

About this Structure

1XPH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of DC-SIGNR with a portion of its repeat domain lends insights to modeling of the receptor tetramer., Snyder GA, Colonna M, Sun PD, J Mol Biol. 2005 Apr 15;347(5):979-89. PMID:15784257

Page seeded by OCA on Sun Jul 27 14:19:18 2008

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