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1xps

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[[Image:1xps.jpg|left|200px]]
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{{STRUCTURE_1xps| PDB=1xps | SCENE= }}
{{STRUCTURE_1xps| PDB=1xps | SCENE= }}
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'''BOVINE RIBONUCLEASE A (PHOSPHATE-FREE) (93 % HUMIDITY)'''
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===BOVINE RIBONUCLEASE A (PHOSPHATE-FREE) (93 % HUMIDITY)===
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==Overview==
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The structures of a new crystal form of ribonuclease A and its low-humidity variant, each containing two crystallographically independent molecules, have been determined and refined. A detailed comparison of these structures with those of the other known crystal forms of the enzyme, which have different packing arrangements and solvent composition, leads to a meaningful delineation of the rigid and flexible regions of the protein molecule and the nature of its plasticity. Many of the water molecules which are common to all the structures are involved in bridging different regions of the protein molecule, thus emphasizing the role of water in stabilizing the tertiary structure. The analysis of the structures shows that for a given N or O atom, the level of hydration increases with accessible surface area, but levels off at an area of about 10 A2. Generally, the hydration level tends to drop when the area increases beyond about 20 A2. This drop correlates with an increase in the displacement parameter. The analysis also suggests that the van der Waals radii and probe radius normally used in accessible surface area calculations are not appropriate for dealing with all situations.
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The line below this paragraph, {{ABSTRACT_PUBMED_10089510}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10089510 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10089510}}
==About this Structure==
==About this Structure==
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[[Category: Sadasivan, C.]]
[[Category: Sadasivan, C.]]
[[Category: Vijayan, M.]]
[[Category: Vijayan, M.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:20:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:18:08 2008''

Revision as of 06:18, 28 July 2008

Image:1xps.png

Template:STRUCTURE 1xps

BOVINE RIBONUCLEASE A (PHOSPHATE-FREE) (93 % HUMIDITY)

Template:ABSTRACT PUBMED 10089510

About this Structure

1XPS is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Plasticity, hydration and accessibility in ribonuclease A. The structure of a new crystal form and its low-humidity variant., Sadasivan C, Nagendra HG, Vijayan M, Acta Crystallogr D Biol Crystallogr. 1998 Nov 1;54(Pt 6 Pt 2):1343-52. PMID:10089510

Page seeded by OCA on Mon Jul 28 09:18:08 2008

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