1xqh

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[[Image:1xqh.jpg|left|200px]]
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{{Seed}}
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[[Image:1xqh.png|left|200px]]
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{{STRUCTURE_1xqh| PDB=1xqh | SCENE= }}
{{STRUCTURE_1xqh| PDB=1xqh | SCENE= }}
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'''Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH'''
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===Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH===
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==Overview==
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p53 is a tumour suppressor that regulates the cellular response to genotoxic stresses. p53 is a short-lived protein and its activity is regulated mostly by stabilization via different post-translational modifications. Here we report a novel mechanism of p53 regulation through lysine methylation by Set9 methyltransferase. Set9 specifically methylates p53 at one residue within the carboxyl-terminus regulatory region. Methylated p53 is restricted to the nucleus and the modification positively affects its stability. Set9 regulates the expression of p53 target genes in a manner dependent on the p53-methylation site. The crystal structure of a ternary complex of Set9 with a p53 peptide and the cofactor product S-adenosyl-l-homocysteine (AdoHcy) provides the molecular basis for recognition of p53 by this lysine methyltransferase.
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The line below this paragraph, {{ABSTRACT_PUBMED_15525938}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15525938 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15525938}}
==About this Structure==
==About this Structure==
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[[Category: Set-domain]]
[[Category: Set-domain]]
[[Category: Set9-p53 complex]]
[[Category: Set9-p53 complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:22:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:34:15 2008''

Revision as of 07:34, 28 July 2008

Image:1xqh.png

Template:STRUCTURE 1xqh

Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH

Template:ABSTRACT PUBMED 15525938

About this Structure

1XQH is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Regulation of p53 activity through lysine methylation., Chuikov S, Kurash JK, Wilson JR, Xiao B, Justin N, Ivanov GS, McKinney K, Tempst P, Prives C, Gamblin SJ, Barlev NA, Reinberg D, Nature. 2004 Nov 18;432(7015):353-60. Epub 2004 Nov 3. PMID:15525938

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