2ayp
From Proteopedia
(New page: 200px<br /> <applet load="2ayp" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ayp, resolution 2.90Å" /> '''Crystal Structure o...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:2ayp.gif|left|200px]]<br /> | + | [[Image:2ayp.gif|left|200px]]<br /><applet load="2ayp" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2ayp" size=" | + | |
caption="2ayp, resolution 2.90Å" /> | caption="2ayp, resolution 2.90Å" /> | ||
'''Crystal Structure of CHK1 with an Indol Inhibitor'''<br /> | '''Crystal Structure of CHK1 with an Indol Inhibitor'''<br /> | ||
| Line 8: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2AYP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 43A as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http:// | + | 2AYP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=43A:'>43A</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AYP OCA]. |
==Reference== | ==Reference== | ||
| Line 25: | Line 24: | ||
[[Category: protein-inhibitor complex]] | [[Category: protein-inhibitor complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:15:13 2008'' |
Revision as of 15:15, 15 February 2008
|
Crystal Structure of CHK1 with an Indol Inhibitor
Overview
Chk1 inhibitors have emerged as a novel class of neoplastic agents for, abrogating the G2 DNA damage checkpoint arrest. Analogs of the Chk1, inhibitor, 3-ethylidene-1,3-dihydro-indol-2-one, were synthesized and, tested in vitro for their inhibitory activities. The most promising, compound identified from this series is analog 28, which possesses potent, enzymatic and cellular activities.
About this Structure
2AYP is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Full crystallographic information is available from OCA.
Reference
Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors., Lin NH, Xia P, Kovar P, Park C, Chen Z, Zhang H, Rosenberg SH, Sham HL, Bioorg Med Chem Lett. 2006 Jan 15;16(2):421-6. Epub 2005 Oct 18. PMID:16242328
Page seeded by OCA on Fri Feb 15 17:15:13 2008
