1xqq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1xqq.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1xqq.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1xqq| PDB=1xqq | SCENE= }}
{{STRUCTURE_1xqq| PDB=1xqq | SCENE= }}
-
'''Simultaneous determination of protein structure and dynamics'''
+
===Simultaneous determination of protein structure and dynamics===
-
==Overview==
+
<!--
-
We present a protocol for the experimental determination of ensembles of protein conformations that represent simultaneously the native structure and its associated dynamics. The procedure combines the strengths of nuclear magnetic resonance spectroscopy--for obtaining experimental information at the atomic level about the structural and dynamical features of proteins--with the ability of molecular dynamics simulations to explore a wide range of protein conformations. We illustrate the method for human ubiquitin in solution and find that there is considerable conformational heterogeneity throughout the protein structure. The interior atoms of the protein are tightly packed in each individual conformation that contributes to the ensemble but their overall behaviour can be described as having a significant degree of liquid-like character. The protocol is completely general and should lead to significant advances in our ability to understand and utilize the structures of native proteins.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15650731}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15650731 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15650731}}
==About this Structure==
==About this Structure==
-
1XQQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQQ OCA].
+
1XQQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQQ OCA].
==Reference==
==Reference==
Line 29: Line 33:
[[Category: Signaling protein]]
[[Category: Signaling protein]]
[[Category: Ubiquitin]]
[[Category: Ubiquitin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:22:55 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:27:40 2008''

Revision as of 02:27, 29 July 2008

Image:1xqq.png

Template:STRUCTURE 1xqq

Simultaneous determination of protein structure and dynamics

Template:ABSTRACT PUBMED 15650731

About this Structure

1XQQ is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Simultaneous determination of protein structure and dynamics., Lindorff-Larsen K, Best RB, Depristo MA, Dobson CM, Vendruscolo M, Nature. 2005 Jan 13;433(7022):128-32. PMID:15650731

Page seeded by OCA on Tue Jul 29 05:27:40 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xqq"
Personal tools