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1xr1

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{{STRUCTURE_1xr1| PDB=1xr1 | SCENE= }}
{{STRUCTURE_1xr1| PDB=1xr1 | SCENE= }}
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'''Crystal structure of hPim-1 kinase in complex with AMP-PNP at 2.1 A Resolution'''
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===Crystal structure of hPim-1 kinase in complex with AMP-PNP at 2.1 A Resolution===
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==Overview==
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Pim-1 kinase is a member of a distinct class of serine/threonine kinases consisting of Pim-1, Pim-2, and Pim-3. Pim kinases are highly homologous to one another and share a unique consensus hinge region sequence, ER-PXPX, with its two proline residues separated by a non-conserved residue, but they (Pim kinases) have &lt;30% sequence identity with other kinases. Pim-1 has been implicated in both cytokine-induced signal transduction and the development of lymphoid malignancies. We have determined the crystal structures of apo Pim-1 kinase and its AMP-PNP (5'-adenylyl-beta,gamma-imidodiphosphate) complex to 2.1-angstroms resolutions. The structures reveal the following. 1) The kinase adopts a constitutively active conformation, and extensive hydrophobic and hydrogen bond interactions between the activation loop and the catalytic loop might be the structural basis for maintaining such a conformation. 2) The hinge region has a novel architecture and hydrogen-bonding pattern, which not only expand the ATP pocket but also serve to establish unambiguously the alignment of the Pim-1 hinge region with that of other kinases. 3) The binding mode of AMP-PNP to Pim-1 kinase is unique and does not involve a critical hinge region hydrogen bond interaction. Analysis of the reported Pim-1 kinase-domain structures leads to a hypothesis as to how Pim kinase activity might be regulated in vivo.
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==About this Structure==
==About this Structure==
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[[Category: White, A.]]
[[Category: White, A.]]
[[Category: Protein kinase fold]]
[[Category: Protein kinase fold]]
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Revision as of 10:04, 27 July 2008

Image:1xr1.png

Template:STRUCTURE 1xr1

Crystal structure of hPim-1 kinase in complex with AMP-PNP at 2.1 A Resolution

Template:ABSTRACT PUBMED 15525646

About this Structure

1XR1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase., Qian KC, Wang L, Hickey ER, Studts J, Barringer K, Peng C, Kronkaitis A, Li J, White A, Mische S, Farmer B, J Biol Chem. 2005 Feb 18;280(7):6130-7. Epub 2004 Nov 3. PMID:15525646

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