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1xs7

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[[Image:1xs7.gif|left|200px]]
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{{STRUCTURE_1xs7| PDB=1xs7 | SCENE= }}
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'''Crystal Structure of a cycloamide-urethane-derived novel inhibitor bound to human brain memapsin 2 (beta-secretase).'''
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===Crystal Structure of a cycloamide-urethane-derived novel inhibitor bound to human brain memapsin 2 (beta-secretase).===
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==Overview==
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A series of novel macrocyclic amide-urethanes was designed and synthesized based upon the X-ray crystal structure of our lead inhibitor (1, OM99-2 with eight residues) bound to memapsin 2. Ring size and substituent effects have been investigated. Cycloamide-urethanes containing 14- to 16-membered rings exhibited low nanomolar inhibitory potencies against human brain memapsin 2 (beta-secretase).
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(as it appears on PubMed at http://www.pubmed.gov), where 15582402 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15582402}}
==About this Structure==
==About this Structure==
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[[Category: Drug design]]
[[Category: Drug design]]
[[Category: Memapsin2]]
[[Category: Memapsin2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:26:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:01:33 2008''

Revision as of 21:01, 28 July 2008

Image:1xs7.png

Template:STRUCTURE 1xs7

Crystal Structure of a cycloamide-urethane-derived novel inhibitor bound to human brain memapsin 2 (beta-secretase).

Template:ABSTRACT PUBMED 15582402

About this Structure

1XS7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase)., Ghosh AK, Devasamudram T, Hong L, DeZutter C, Xu X, Weerasena V, Koelsch G, Bilcer G, Tang J, Bioorg Med Chem Lett. 2005 Jan 3;15(1):15-20. PMID:15582402

Page seeded by OCA on Tue Jul 29 00:01:33 2008

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