1xt9

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{{STRUCTURE_1xt9| PDB=1xt9 | SCENE= }}
{{STRUCTURE_1xt9| PDB=1xt9 | SCENE= }}
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'''Crystal Structure of Den1 in complex with Nedd8'''
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===Crystal Structure of Den1 in complex with Nedd8===
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==Overview==
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The Nedd8 conjugation pathway is conserved from yeast to humans and is essential in many organisms. Nedd8 is conjugated to cullin proteins in a process that alters SCF E3 ubiquitin ligase activity, and it is presumed that Nedd8 deconjugation would reverse these effects. We now report the X-ray structures of the human Nedd8-specific protease, Den1, in a complex with the inhibitor Nedd8 aldehyde, thus revealing a model for the tetrahedral transition state intermediate generated during proteolysis. Although Den1 is closely related to the SUMO-specific protease family (Ulp/Senp family), structural analysis of the interface suggests determinants involved in Nedd8 selectivity by Den1 over other ubiquitin-like family members and suggests how the Ulp/Senp architecture has been modified to interact with different ubiquitin-like modifiers.
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(as it appears on PubMed at http://www.pubmed.gov), where 15567417 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15567417}}
==About this Structure==
==About this Structure==
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[[Category: Cysteine protease]]
[[Category: Cysteine protease]]
[[Category: Ubiquitin-like]]
[[Category: Ubiquitin-like]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:29:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:51:40 2008''

Revision as of 20:51, 27 July 2008

Image:1xt9.png

Template:STRUCTURE 1xt9

Crystal Structure of Den1 in complex with Nedd8

Template:ABSTRACT PUBMED 15567417

About this Structure

1XT9 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1., Reverter D, Wu K, Erdene TG, Pan ZQ, Wilkinson KD, Lima CD, J Mol Biol. 2005 Jan 7;345(1):141-51. PMID:15567417

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